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TranscriptomicsGene Expression differences in Hepatic Parenchyma and Portal Tracts in Hepatitis C Virus Infected Subjects with High and Low Fibrosis
Background & Aims: Chronic hepatitis C virus (HCV) infection is complicated by hepatic fibrosis. Hypothesizing that fibrogenic signals may originate in cells susceptible to HCV infection, gene expression of hepatocytes was analyzed from persons with chronic HCV at different stages of liver fibrosi...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-33650 | biostudies-arrayexpress
TranscriptomicsMicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity ...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-41737 | biostudies-arrayexpress
UnknownMitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.
Not available
S-EPMC5123076 | biostudies-literature
TranscriptomicsMutant PI3K cooperates with HER2 to promote mammary tumor formation and induces trastuzumab resistance in vivo
HER2 (ERBB2) gene amplification and PIK3CA mutations often co-occur in breast cancer, and aberrant activation of the PI3K pathway has been implicated in resistance to HER2-directed therapies. We have created a mouse model of HER2-overexpressing (HER2+), PIK3CAH1047R-mutant breast cancer. Mice expres...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-41118 | biostudies-arrayexpress
UnknownThe adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells.
Not available
S-EPMC3436965 | biostudies-literature
UnknownProstaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4.
Not available
S-EPMC4203853 | biostudies-literature
UnknownMicrobial Succession under Freeze-Thaw Events and Its Potential for Hydrocarbon Degradation in Nutrient-Amended Antarctic Soil.
Not available
S-EPMC8000410 | biostudies-literature
UnknownSilencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth.
Not available
S-EPMC6068349 | biostudies-literature
UnknownThe adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.
Not available
S-EPMC4402263 | biostudies-literature
UnknownDirect reprogramming of human fibroblasts into insulin-producing cells using transcription factors.
Not available
S-EPMC10039074 | biostudies-literature
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