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TranscriptomicsChromatin accessibility of a model of CRISPR-mediated insulator disruption in the MMP locus in triple-negative breast cancer cell lines
Using CRISPR-Cas9 technology, we stably disrupted an insulator element in two different TNBC cell lines. The aim of this experiment was to characterize the chromatin accessibility profile using ATAC-seq. For this experiment, we selected three biological replicates of MDA-MB-231 (WT and IE8dis) and M...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-12821 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of core glioma stem cells: a novel glioblastoma cell population with diminished antigen presentation
Using induced pluripotent stem cell (iPSC) technology, we reprogrammed GBM derived cells (GBM-DCs) into embryonic-like cells termed as induced core-GSCs (ic-GSCs). The aim of this experiment was to characterize the DNA methylation profile of ic-GSCs using the Infinium MethylationEPIC array BeadChip ...
ORGANISM(S): Homo sapiens 
2022-05-11 | E-MTAB-10978 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of core glioma stem cells: a novel glioblastoma cell population with diminished antigen presentation
Using induced pluripotent stem cell (iPSC) technology, we reprogrammed GBM derived cells (GBM-DCs) into embryonic-like cells termed as induced core-GSCs (ic-GSCs). The aim of this experiment was to characterize the transcriptomic profile of ic-GSCs using RNA-seq. For this experiment, we selected thr...
ORGANISM(S): Homo sapiens 
2022-05-11 | E-MTAB-10977 | biostudies-arrayexpress
TranscriptomicsChromatin architecture profiling of a model of CRISPR-mediated insulator disruption in the MMP locus in triple-negative breast cancer cell lines
Using CRISPR-Cas9 technology, we stably disrupted an insulator element in two different TNBC cell lines. The aim of this experiment was to characterize the chromatin architecture profile using Hi-C. For this experiment, we selected three biological replicates of MDA-MB-231 (WT and IE8dis).
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-12825 | biostudies-arrayexpress
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