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TranscriptomicsGenes regulated by PCK Inhibitors, enzastaurin and Go, in CAL-27 cells, a SCCHN cell line
Efficacy of the Multi-Kinase Inhibitor Enzastaurin is Dependent on Cellular Signaling Context Testing a panel of SCCHN cell lines revealed variable sensitivity to enzastaurin which correlated significantly with baseline cyclin D1 protein expression. Moreover, sensitivity and resistance could be reve...
ORGANISM(S): Homo sapiens 
2010-07-12 | E-GEOD-22811 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of enzastaurin-treated B cell lymphoma RL cells
Follicular lymphoma (FL) is an indolent lymphoma associated with follicular center B cells, and typically contains the Bcl-2 chromosomal translocation t(14;18), which leads to overexpression of the anti-apoptotic intracellular protein Bcl-2. FLs are sensitive to chemotherapy; however, patient relaps...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-24183 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of enzastaurin-treated B cell lymphoma RL cells
Follicular lymphoma (FL) is an indolent lymphoma associated with follicular center B cells, and typically contains the Bcl-2 chromosomal translocation t(14;18), which leads to overexpression of the anti-apoptotic intracellular protein Bcl-2. FLs are sensitive to chemotherapy; however, patient relaps...
ORGANISM(S): Homo sapiens 
2011-09-15 | GSE24183 | GEO
GenomicsThe PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
PRJNA451011 | ENA
TranscriptomicsThe PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
Enzastaurin is a Protein Kinase C-β selective inhibitor that was developed to treat cancers. Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and fear-conditioned learning and memory with lower lev...
ORGANISM(S): Rattus norvegicus 
2018-04-20 | GSE113327 | GEO
TranscriptomicsGenes regulated by PCK Inhibitors, enzastaurin and Go, in CAL-27 cells, a SCCHN cell line
Efficacy of the Multi-Kinase Inhibitor Enzastaurin is Dependent on Cellular Signaling Context Testing a panel of SCCHN cell lines revealed variable sensitivity to enzastaurin which correlated significantly with baseline cyclin D1 protein expression. Moreover, sensitivity and resistance could be reve...
ORGANISM(S): Homo sapiens 
2010-07-12 | GSE22811 | GEO
UnknownThe protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.
Not available
S-EPMC3257235 | biostudies-literature
UnknownA phase I trial of enzastaurin in patients with recurrent gliomas.
Not available
S-EPMC7227612 | biostudies-literature
UnknownThe PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats.
Not available
S-EPMC5988320 | biostudies-literature
UnknownEnzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.
Not available
S-EPMC4627332 | biostudies-literature
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