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UnknownAlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach.
Not available
S-EPMC11223865 | biostudies-literature
TranscriptomicsSHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Triple Negative Breast cancer accounts for some of the most aggressive types of breast cancer. By interrogating clinical datasets, we found that the activities of p63 and Hypoxia-Inducible-Factors (HIFs), two master regulators of the invasive and metastatic cancer cell phenotype are linked in TNBC ...
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-33950 | biostudies-arrayexpress
UnknownSingle-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells.
Not available
S-EPMC8097075 | biostudies-literature
UnknownCalreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants.
Not available
S-EPMC6646313 | biostudies-literature
UnknownAllele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells.
Not available
S-EPMC10861943 | biostudies-literature
TranscriptomicsWidespread association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth [gene expression]
The goal of this study was to identify YAP/TAZ direct transcriptional targets and transcriptional partners, through ChIP-sequencing and gene expression profiling. Keywords: Expression profiling by array MDA-MB-231 cells growing at low confluence in standard growth conditions were transfected with t...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-66082 | biostudies-arrayexpress
UnknownRegeneration of the entire human epidermis using transgenic stem cells.
Not available
S-EPMC6283270 | biostudies-literature
TranscriptomicsMicroarray experiment of murine macrophages co-cultured with neural stem cells in the presences of LPS
This experiment aimed at characterising the modulatory role of murine induced Neural Stem Cells (iNSCs) and Neural Stem Cells (NSCs) on macrophages (MPs) exposed to LPS in vitro. Naïve MPs were polarized into an M1-like phenotype with LPS, and then co-cultured with 1:1 ratios of iNSCs in a trans-we...
ORGANISM(S): Mus musculus 
2018-01-01 | E-MTAB-5579 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (SW480)
To investigate the role of TAZ downstream of the abberrant Wnt signaling in CRC cells, we compared the expression profiles of parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or reconstituted with wild type APC and transfected with siControl Keywords: expression...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39904 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (MII)
To investigate the role of TAZ downstream of APC and beta-catenin in mammary epithelial cells cells, we compared the expression profiles of MCF10-T1k (MII) cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Keywords: expression profiling by array We colle...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39902 | biostudies-arrayexpress
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