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TranscriptomicsTranscription profiling of human eosinophilic esophagitis biopsies, cultured and stimulated with IL-13
3 eosinophilic esophagitis biopsies, cultured and stimulated with IL-13 : each of them was either left unstimulated or stimulated (100ng for 48h); We used microarray to uncover the IL-13-induced genes in esophageal epithelial cells of the esophagus Experiment Overall Design: 3 biopsies from EE patie...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-8853 | biostudies-arrayexpress
TranscriptomicsDNA methylation in oesophageal biopsies of children diagnosed with Eosinophilic Oesophagitis (EoE) and controls
Eosinophilic oesophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. In this pilot study, we performed genome-wide DNA methylation analyses on oesophageal biopsies obtained from children diagnosed with EoE (at diagnosis and after treatment) and matched controls....
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-9824 | biostudies-arrayexpress
TranscriptomicsAnalysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing
We utilized RNA sequencing to expand and better define the molecular entities involved in the transcriptional programming within the eosphagus in eosinophilic esophagitis (EoE) Examination of differentially expressed genes from RNA sequencing data performed on esophageal biopsy specimen from 6 healt...
ORGANISM(S): Homo sapiens 
2014-06-27 | E-GEOD-58640 | biostudies-arrayexpress
TranscriptomicsmiRNA Profiling in mucosal biopsies of Eosinophilic Esophagitis patients pre and post glucocorticoid steroid treatment
Eosinophlic esophagitis (EoE) is increasely recognized as an antigen-drived disorder. The goal of this study is to reveal the miRNA expression changes in EoE before and after a successful glucocorticoid steroid treatment. Total RNA was extracted from the esophageal epithelial layers of 5 paired para...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-36726 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Eosinophilic Esophagitis: Identification and Involvement of the Minichromosome Maintenance Complex as a Driver of Esophageal Basal Zone Hyperplasia
To uncover molecular drivers of Eosinophilic Esophagitis (EoE), a global proteome screen of the esophageal biopsies from individuals with and without EoE was performed.
ORGANISM(S): Homo sapiens (Human) 
2023-08-01 | PXD040030 | Pride
Lfq Proteomics Eosinophilic esophagitis 
TranscriptomicsTaqMan microRNA array of human serum from children with eosinophilic esophagitis
Serum from children with active and inactive treated eosinophilic esophagitis was analyzed for detection of microRNA Individual serum samples from children with eosinophilic esophagitis were analyzed for detection of microRNA. (n=5 for active EoE and n=5 for inactive EoE)
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-55793 | biostudies-arrayexpress
TranscriptomicsNanostring nCounter human miRNA assay (v1) of eosinophilic esophagitis
Nanostring nCounter Human miRNA assay (v1) of esophageal mucosal biopsies from children with eosinophilic esophagitis and controls Individual esophageal mucosal biopsies from children with eosinoniphilic esophagitis and controls were analysed for detection of microRNA
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-55794 | biostudies-arrayexpress
TranscriptomicsMicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Glucocorticoid Steroid Treatment and Relationship with mRNA Target Expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-36727 | biostudies-arrayexpress
ProteomicsPersistent epithelial barrier dysfunction and Periostin accumulation in histologic remission Eosinophilic Esophagitis
Patients with Eosinophilic esophagitis (EoE) require long-lasting resolution of inflammation to prevent fibrostenosis and dysphagia. However, the dissociation between symptoms and histologic improvement suggests persistent molecular drivers despite remission. We aimed to characterize persisting mole...
ORGANISM(S): Homo sapiens (Human) 
2024-09-23 | PXD052250 | Pride
Fibrosis Molecular remission Histologic remission Proteome Epithelial barrier dysfunction Eosinophilic esophagitis 
ProteomicsProteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology
Background: Eosinophilic esophagitis (EoE) is a chronic non-IgE-mediated allergic disease of the esophagus. An unbiased proteomics approach was performed to investigate pathophysiological changes in esophageal epithelium. Additionally, an RNAseq-based transcriptomic analysis in paired samples was al...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD062507 | Pride
Basic mechanisms  eosinophilic esophagitis  epithelium  proteomic 
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