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Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS833 | MetaboLights
EPIC
Heteromeric protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to preci...
ORGANISM(S): Caenorhabditis elegans 
2019-07-16 | PXD011182 | Pride
EPIC-HPS
circSHAPE-MaP of EPIC
This study aimed to determine skeletal muscle DNA methylation changes in a cohort of volunteers with a range of insulin sensitivities following 8-weeks of supervised exercise training. We studied 13 sedentary participants (5M/8F, 34.6 ± 3.1 years) and performed euglycemic hyperinsulinemic clamps wit...
ORGANISM(S): Homo sapiens 
EPIC array data from 72 tumor samples with muscle invasive bladder cancer.
Uli-Epic: A cutting-edge library construction strategy for profiling ultra-limited RNA modifications [Uli-Epic GLORI]
We used the Illumina Infinium HumanMethylation EPIC beadchip array to profile 31 pediatric tumors with the histological diagnosis of anaplastic pilocytic astrocyoma (PA). PA with anaplasia has been defined in the 2016 WHO classification as a tumor with PA morphology and >4 mitoses per 10 HPF, with o...
ORGANISM(S): Homo sapiens 
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