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MetabolomicsCell of origin epigenetic priming determines susceptibility to Tet2 mutation

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
TranscriptomicsInvolvement of the Chromatin Modifier ATX1 and of the Arabidopsis Myotubularin Homolog (MYO1) in the Response to Drought
Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 influences gene expression and factors that modulate ATX1 activity would affect indirectly the expression of ATX1-regulated genes. Here, we demonstrate that dehydration ...
ORGANISM(S): Arabidopsis thaliana 
2010-05-07 | E-GEOD-15577 | biostudies-arrayexpress
TranscriptomicsThe epigenetic modifier Fam208a is required to maintain epiblast cell potency
Gastrulation initiates with the formation of the primitive streak, during which, cells of the epiblast delaminate to form the mesoderm and definitive endoderm. At this stage, the pluripotent cell population of the epiblast undergoes very rapid cellular proliferation and extensive epigenetic programm...
ORGANISM(S): Mus musculus 
2017-06-01 | E-MTAB-5357 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E10.5 female embryos wild-type and mutant for Smchd1
To investigate the role of the Smchd1 protein in epigenetic silencing of autosomal loci, we carried out a comparative microarray gene expression analysis of wild-type and Smchd1-/- female embryos at E10.5. Embryos were collected at E10.5 after natural mating, sexed and genotyped. Total RNAs were ext...
ORGANISM(S): Mus musculus 
2012-04-01 | E-MTAB-921 | biostudies-arrayexpress
UnknownThe epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Not available
S-EPMC5570896 | biostudies-literature
GenomicsSox4 is a master regulator of epithelial-mesenchymal transition (EMT) by controlling Ezh2 expression and epigenetic reprogramming
Gene expression profiling has uncovered the transcription factor Sox4 with up-regulated activity during TGFβ-induced EMT in normal and cancerous breast epithelial cells. Sox4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. Among several EMT-r...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-45579 | biostudies-arrayexpress
UnknownL-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
Not available
S-EPMC4286872 | biostudies-literature
ProteomicsThe histone modifier KANSL2 is an actionable biomarker for response to epigenetic modifiers in multiple myeloma
Epigenetic aberrations are key drivers of multiple myeloma (MM), yet targeted therapies exploiting epigenetic alterations have not been established. By integrating clinical and molecular MM patient data sets with an unbiased genetic in vivoscreen, we identified KAT8 regulatory NSL complex subunit 2 ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-22 | PXD066205 | Pride
Histone acetylation Hdac inhibitors Kansl2 Bet inhibitors Biomarker Multiple myeloma 
UnknownCombined epigenetic/genetic study identified an ALS age of onset modifier.
Not available
S-EPMC8066440 | biostudies-literature
UnknownThe epigenetic modifier DNMT3A is necessary for proper otic placode formation.
Not available
S-EPMC4783191 | biostudies-literature
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