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MetabolomicsReversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies
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ORGANISM(S): Mus musculus 
ST001838 | MetabolomicsWorkbench
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
ProteomicsEpigenetic Silencing by SETDB1 Suppresses Tumor-cell Intrinsic Immunogenicity
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi A, Ishizuka JJ, Kim S, Klaeger S, Knudsen NH, Miller BC, Nguyen T, Olander K, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary M, Zimmer M, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Mangu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-12-11 | MSV000086580 | MassIVE
TranscriptomicsEnvironment-responsive transcription factors bind proto-silencer elements and regulate subtelomeric silencing
Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of different stress response pathways, and control of lifespan. Subtelomeric DNA is characterized...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-02 | E-GEOD-21852 | biostudies-arrayexpress
GenomicsNucleoporin Nup153 Regulates Stem Cell Pluripotency through Gene Silencing
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), the transport channels that mediate nuclear transport. Recent evidence suggest that several Nups have additional roles in controlling the activation and silencing of developme...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-64008 | biostudies-arrayexpress
GenomicsMORC family ATPases required for heterochromatin condensation and gene silencing
Transposable elements (TEs) and DNA repeats are commonly targeted by DNA and histone methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis genes, CRT1 and CRH6, which cause de-repression of DNA-methylated genes and TEs, but no losses of DNA or histone methylatio...
ORGANISM(S): Arabidopsis thaliana 
2012-05-02 | E-GEOD-37644 | biostudies-arrayexpress
TranscriptomicsTranscriptional gene silencing mediated by interplay of MOM1 and Pol V
In plants, multiple levels of epigenetic control suppress transposon movement and permit somatic as well as transgenerational transmission of gene expression patterns. A variety of factors are involved that establish and/or maintain epigenetic marks, such as covalent modification of DNA and histones...
ORGANISM(S): Arabidopsis thaliana 
2010-06-19 | E-GEOD-17940 | biostudies-arrayexpress
TranscriptomicsTranscriptional gene silencing by Arabidopsis Microrchidia homologues involves the formation of heteromers
Epigenetic gene silencing is of central importance to maintain genome integrity and is mediated by an elaborate interplay between DNA methylation, histone posttranslational modifications and chromatin remodeling complexes. DNA methylation and repressive histone marks usually correlate with transcrip...
ORGANISM(S): Arabidopsis thaliana 
2014-06-01 | E-GEOD-54677 | biostudies-arrayexpress
TranscriptomicsAn epigenetic role for maternally inherited piRNAs in transposon silencing
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. Here, we find that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can pr...
ORGANISM(S): Drosophila melanogaster 
2008-11-28 | E-GEOD-13081 | biostudies-arrayexpress
TranscriptomicsGenomewide view of gene silencing by small interfering RNAs
RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells that directs the degradation of messenger RNAs homologous to short double-stranded RNAs termed small interfering RNA (siRNA). The ability of siRNA to direct gene silencing in mammalian cells has raised the pos...
ORGANISM(S): Homo sapiens 
2005-12-14 | E-GEOD-3825 | biostudies-arrayexpress
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