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MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
ProteomicsEpi-proteomic assessment of backpain therapy
This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices. We report that the therapy improves agility, attenuates backpain, and also triggers healthier habits. We find that a subset of participants´ histone methylation and a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-21 | PXD050113 | Pride
Pbmc Histone ptms Buccal swabs Proteome Backpain therapy 
TranscriptomicsEpigenetic therapy for Friedreich ataxia.
We set out to investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to evaluate safety and surrogate markers of efficacy in a phase I clinical trial in patients. In the neuronal cell model, H...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-65399 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression after epigentic targeted therapy in T-cell prolymphocytic leukemia (T-PLL)
Epigenetic therapy overcame alemtuzumab resistance in patients with relapsed T-cell prolymphocytic leukemia and induced the expression of treatment related genes. Method: patient PBMCs from Ficoll, normal patient PBMCS enriched for CD3+/CD8+ or CD3+/CD8+/CD45RA+/CCR7- were extracted in Trizol. Con...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-67368 | biostudies-arrayexpress
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap
ORGANISM(S): Homo Sapiens 
2024-08-28 | PXD055421 |
ProteomicsEpigenetic therapy activates TE-chimeric transcripts to provide additional source of antigens in glioblastoma stem cells
Cancer-specific coding mutations can create neoantigens that can be presented on the cell surface of tumors to trigger immunogenic clearance1–4. However, current cancer vaccine approaches have not been universally effective5; this is especially true in tumors with a low mutational burden which, in t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-05 | PXD039893 | Pride
Transposable element Glioblastoma Immunotherapy Epigenetic treatment 
GenomicsEpigenetic therapy induces transcription of Inverted SINEs and ADAR1 dependency
Epigenetic therapy induces transcription of Inverted SINEs and ADAR1 dependency
PRJNA607783 | ENA
GenomicsOvercoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy
PRJNA882766 | ENA
GenomicsTarget Specificity of Epigenetic Therapy
Target Specificity of Epigenetic Therapy
PRJNA312618 | ENA
TranscriptomicsEpigenetic events in early breast cancer
Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8007 | biostudies-arrayexpress
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