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TranscriptomicsAtaxia-telangiectasia cerebellar cortex expression
Cerebellar cortex expression in ataxia-telangiectasia patients and normal controls. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uni...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61019 | biostudies-arrayexpress
TranscriptomicsSelective loss of 5hmC links to A-T Purkinje cell vulnerability
This SuperSeries is composed of the SubSeries listed below. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uniquely vulnerable to ATM-...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61169 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation profiling reveals epigenetic changes in the rat nucleus accumbens associated with cross-generational effects of adolescent THC exposure
Drug exposure during critical periods of development is known to have lasting effects, increasing one’s risk for developing mental health disorders. Emerging evidence has also indicated the possibility for drug exposure to even impact subsequent generations. Our previous work demonstrated that adole...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-69984 | biostudies-arrayexpress
GenomicsSelective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [NicE-seq]
Selective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [NicE-seq]
PRJNA1142009 | ENA
GenomicsSelective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [CUT&Run]
Selective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [CUT&Run]
PRJNA1142010 | ENA
UnknownHijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer.
Not available
S-EPMC6063490 | biostudies-literature
UnknownEnvironmental Influences Measured by Epigenetic Clock and Vulnerability Components at Birth Impact Clinical ASD Heterogeneity.
Not available
S-EPMC8467464 | biostudies-literature
GenomicsSelective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [RNA-Seq]
Selective NSD2 Inhibition Reveals an Epigenetic Vulnerability of KRAS-Driven Cancers [RNA-Seq]
PRJNA1142008 | ENA
UnknownClinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis.
Not available
S-EPMC9101730 | biostudies-literature
UnknownEpigenetic control of topoisomerase 1 activity presents a cancer vulnerability.
Not available
S-EPMC12343833 | biostudies-literature
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