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TranscriptomicsGenetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans
The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated a subunits of hypoxia-inducible factor (HIF). Although studies of VHL defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysr...
ORGANISM(S): Caenorhabditis elegans 
2005-07-20 | E-GEOD-2963 | biostudies-arrayexpress
TranscriptomicsExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown. We compared acute post-MI gene e...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-19322 | biostudies-arrayexpress
TranscriptomicsExpression profiles of (40,XX) and (39,XO) females
Gobal expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice with the aim of identifying which genes are expressed from both X chromosomes as well as those genes deregulated in X chromosome monosomy. Keywords: Expression profiling by array For ea...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-13520 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes
Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this d...
ORGANISM(S): Homo sapiens 
2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of epithelial and fibroblast cells in chronic rhinosinusitis
Chronic rhinosinusitis without polyps (CRSsNP) is typified by inflammation of the sinonasal epithelium and the development of fibrosis. The precise pathophysiology of this common condition remains elusive. Here we aim to investigate the transcriptome (RNA transcripts in the cell) of the component ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69093 | biostudies-arrayexpress
TranscriptomicsRobust enumeration of cell subsets from tissue expression profiles (BeadChip)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with r...
ORGANISM(S): Homo sapiens 
2015-03-29 | E-GEOD-65133 | biostudies-arrayexpress
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
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