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UnknownPathogen Detection Using Metagenomic Next-Generation Sequencing of Plasma Samples from Patients with Sepsis in Uganda.
Not available
S-EPMC9927450 | biostudies-literature
TranscriptomicsGene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells
Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LC...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17211 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
TranscriptomicsEffect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of children with a prevalence of 5-10% worldwide. Up to 30% of adults with a history of childhood ADHD maintain symptoms in later life; these adult ADHD patients are severely impaired in social and professional life d...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-52889 | biostudies-arrayexpress
UnknownAssociation of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.
Not available
S-EPMC3485412 | biostudies-literature
TranscriptomicsT Cell Deficiency in Spinal Cord Injury: Altered Locomotor Recovery and Whole-Genome Transcriptional Analysis
T cells undergo autoimmunization following spinal cord injury (SCI) and play both protective and destructive roles during the recovery process. T-cell deficient athymic nude (AN) rats recover better than immunocompetent Sprague-Dawley (SD) rats following spinal cord transection. In the present study...
ORGANISM(S): Rattus norvegicus 
2015-10-26 | E-GEOD-62760 | biostudies-arrayexpress
TranscriptomicsTime series gene expression data from adult rat tail MNs following spinal cord transection
Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearance of plateau potentials in m...
ORGANISM(S): Rattus norvegicus 
2010-05-27 | E-GEOD-19701 | biostudies-arrayexpress
TranscriptomicsRNA-seq in breast cancer cell lines after manipulation of miR-23b expression
RNA sequencing technology has been carried out in order to evaluate mRNA expression changes after manipulation of miR-23b in both MCF-7 and MDA-MB-231 breast cancer cell lines Our study implicates miR-23b in cytoskeletal remodeling in breast cancer. To evaluate the entire set of genes modulated by m...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37918 | biostudies-arrayexpress
TranscriptomicsExtensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells (miRNA)
Understanding toxicity pathways of engineered nanomaterials (ENM) has recently been brought forward as a key step in 21st century ENM risk assessment. Molecular mechanisms linked to phenotypic end points is a step towards the development of toxicity tests based on key events, which may allow for gro...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-63559 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in hypothalamus of non-recombinant subcongenic-derived F2 mice fed macronutrient selection diets
The specific genes influencing the quantitative variation in macronutrient preference and food intake are virtually unknown. We refined a previously identified mouse chromosome 17 (MMU17) region harboring quantitative trait loci (QTL) with large effects on preferential macronutrient intake-carbohyd...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-60756 | biostudies-arrayexpress
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