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TranscriptomicsEBER2 RNA-induced transcriptome changes identify cellular processes likely targeted during Epstein Barr Virus infection.
Little is known about the physiological role of the EBER1 and 2 nuclear RNAs during Epstein Barr viral infection. The cellular transcription response to EBER2 expression using the wild-type and an internal deletion mutant was determined. Significant changes in gene expression patterns were observed....
ORGANISM(S): Homo sapiens 
2008-10-02 | E-GEOD-11093 | biostudies-arrayexpress
TranscriptomicsDNA methylation epigenotype expanding to non-polycomb target genes, induced by Epstein-Barr virus infection in human gastric cancer
This SuperSeries is composed of the following subset Series: GSE31787: Aberrant DNA methylation epigenotype expanding to non-polycomb target genes, induced by Epstein-Barr virus infection in human gastric cancer [Affymetrix Expression] GSE31788: Aberrant DNA methylation epigenotype expanding to non-...
ORGANISM(S): Homo sapiens 
2012-01-04 | E-GEOD-31789 | biostudies-arrayexpress
TranscriptomicsIdentifying Sites Bound by Epstein Barr Nuclear Antigen 1 (EBNA1) in the Human Genome
Epstein-Barr virus (EBV) is a ubiquitous gammaherpes virus that establishes a life-long latency in over 90% of the world's population. Epstein Barr Nuclear Antigen 1, EBNA1, is the only viral protein consistently detected in all viral latency programs, as well as in all forms of EBV-associated malig...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-13315 | biostudies-arrayexpress
TranscriptomicsThe Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA146a
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2008-01-03 | E-GEOD-10057 | biostudies-arrayexpress
TranscriptomicsAGS cells infected with Epstein Barr Virus
Gene expression profile of AGS gastric carcinoma cell line infected in vitro with Epstein-Barr Virus. Some samples also contain are stably transfected with a dominant negative LMP1 construct. 8 total samples. 4 biological replicates of EBV infected cells, 2 biological replicates with EBV infected ...
ORGANISM(S): Homo sapiens 
2012-05-07 | E-GEOD-37753 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of epithelial cells infected with microRNA-negative and -positive Epstein-Barr viruses
The Epstein-Barr virus (EBV) encodes its own microRNAs (miRNAs); however, their biological roles remain elusive. The commonly used EBV B95-8 strain lacks a 12 kb genomic region, known as BamHI A Rightward Transcripts (BART) locus, which encodes a number of viral miRNAs (BART miRNAs). These miRNAs ar...
ORGANISM(S): Homo sapiens 
2015-02-05 | E-GEOD-58723 | biostudies-arrayexpress
TranscriptomicsEpstein Barr virus Nuclear Antigen 3C regulated genes in Lymphoblastoid Cell Lines
Epstein Barr virus (EBV) nuclear antigen 3C (EBNA3C) is an essential transcription factor for initiating and maintaining human B lymphocyte transformation to lymphoblastoid cell lines (LCLs). To comprehensively identify EBNA3C regulated cell genes in LCLs, oligonucleotide arrays were used to compare...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-24362 | biostudies-arrayexpress
TranscriptomicsInduction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human B cells; relevance to cellular transformation.
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physi...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-45829 | biostudies-arrayexpress
TranscriptomicsThe EBV latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways
This SuperSeries is composed of the following subset Series: GSE10057: The Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA146a GSE10105: Alteration of microRNA gene expression by EBV encoded LMP1 oncogene Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-01-08 | E-GEOD-10107 | biostudies-arrayexpress
TranscriptomicsEpstein–Barr virus (EBV) Rta-mediated cell cycle arrest enables permissive replication of EBV and Kaposi’s sarcoma-associated herpesvirus in 293 cells
Epstein-Barr virus (EBV) Rta is a latent-lytic molecular switch evolutionarily conserved in all gamma-herpesviruses. In previous studies, doxycycline-inducible Rta was shown to potently produce an irreversible G1 arrest followed by cellular senescence in 293 cells. Here, we demonstrate that in this ...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-24587 | biostudies-arrayexpress
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