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Metabolomicsp53 regulates Chaperone-mediated autophagy

p53 protects against the initiation and progression of a plethora of cancers, but the mechanisms underlying this critical function remain incompletely understood. In addition, chaperone-mediated autophagy (CMA) is major form of autophagy unique to vertebrates, yet both its regulation and function...

2026-10-03 | MTBLS13190 | MetaboLights
TranscriptomicsThe eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER ...
ORGANISM(S): Mus musculus 
2012-01-20 | E-GEOD-29929 | biostudies-arrayexpress
UnknownThe ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia.
Not available
S-EPMC10528316 | biostudies-literature
TranscriptomicsNew compounds triggering endoplasmic reticulum stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
We discovered and developed a new series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all tested melanoma cells including those isolated from patients and those that developed resistance to BRAF inhibitors. Our molecule dis...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79071 | biostudies-arrayexpress
GenomicsBombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BIP
Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BIP
PRJNA1138767 | ENA
UnknownUPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor.
Not available
S-EPMC6858872 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis wild-type and atbzip60 mutant plants in response to the ER stress inducer tunicamycin
AtbZIP60 is one of the transcription factors involved in the endoplasmic reticulum (ER) stress response in Arabidopsis. To identify genes under the control of AtbZIP60 during ER stress, we compared the genome-wide expression profiles of wild-type and atbzip60 mutant plants in response to the ER stre...
ORGANISM(S): Arabidopsis thaliana 
2008-11-19 | E-MEXP-1753 | biostudies-arrayexpress
GenomicsDelay of Diabetic Cataract Progression by a Chemical Chaperone Trimethylamine N-Oxide through Alleviating Unfolded-Protein-Induced ER Stress
Delay of Diabetic Cataract Progression by a Chemical Chaperone Trimethylamine N-Oxide through Alleviating Unfolded-Protein-Induced ER Stress
PRJNA1495882 | ENA
UnknownCCDC134 controls TLR biogenesis through the ER chaperone Gp96.
Not available
S-EPMC11629888 | biostudies-literature
GenomicsSEPN1-related myopathy depends on the ER oxidase ERO1 alpha and is responsive to the chemical chaperone TUDCA
SEPN1-related myopathy depends on the ER oxidase ERO1 alpha and is responsive to the chemical chaperone TUDCA
PRJEB64682 | ENA
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