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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
GenomicsPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
Principles of cotranslational mitochondrial protein import revealed by selective ribosome profiling
PRJNA1076084 | ENA
TranscriptomicsThe ß-importin KAP8 (Pse1/Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in Trichoderma reesei
The ascomycete Trichoderma reesei is an industrial producer of cellulolytic and hemicellulolytic enzymes and also serves as a model for investigations on these enzymes and their genes. Most of them are obligatorily dependent on the Zn(II)Cys(VI) transcriptional activator XYR1. XYR1 is constitutively...
ORGANISM(S): Trichoderma reesei 
2015-03-03 | E-GEOD-59600 | biostudies-arrayexpress
UnknownERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.
Not available
S-EPMC3897919 | biostudies-literature
UnknownThe N-terminus of Sec61p plays key roles in ER protein import and ERAD.
Not available
S-EPMC6481919 | biostudies-literature
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044379 | Pride
Contact sites. endoplasmic reticulum. ermes. er-surf. protein import. protein targeting. mitochondria 
OtherPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
The biogenesis of nearly all mitochondrial proteins begins with translation on cytosolic ribosomes. How these proteins are subsequently delivered to mitochondria remains poorly understood. Here, we systematically investigated the coupling of mitochondrial protein translation and import using selecti...
ORGANISM(S): Homo sapiens 
2025-08-01 | GSE255657 | GEO
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria - Data Set 2
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044368 | Pride
Contact sites. endoplasmic reticulum. ermes. er-surf. protein import. protein targeting. mitochondria 
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria - Data Set 1
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044362 | Pride
Yeast membrane contact sites ermes. er-surf. protein import. protein targeting. mitochondria 
ProteomicsThe ER protein Ema19 facilitates the degradation of non-imported mitochondrial precursor proteins
For the biogenesis of mitochondria, hundreds of proteins need to be targeted from the cytosol into the various compartments of this organelle. The intramitochondrial targeting routes these proteins take to reach their respective location in the organelle are well understood. However, the early targe...
ORGANISM(S): Chlamydomonas reinhardtii Saccharomyces cerevisiae (Baker's yeast) 
2021-03-24 | PXD022660 | Pride
Mitochondrial protein import Ae-ms Lc-ms/ms Mitochondria 
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