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MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
GenomicsIncrease in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis
Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis
PRJNA1111056 | ENA
ProteomicsAPEX-based identification of proteins at ER-Mitochondrial contacts sites
Identification of protein promoting ER-mitochondrial contacts using ascorbate peroxidase (APEX) labeling.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-06-20 | MSV000081174 | MassIVE
UnknownER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.
Not available
S-EPMC7588143 | biostudies-literature
UnknownImaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface.
Not available
S-EPMC3178184 | biostudies-literature
UnknownUsing MitER for 3D analysis of mitochondrial morphology and ER contacts.
Not available
S-EPMC10832265 | biostudies-literature
UnknownMul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
Not available
S-EPMC6692330 | biostudies-literature
UnknownER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells.
Not available
S-EPMC5554545 | biostudies-literature
UnknownPeri-mitochondrial actin filaments inhibit Parkin assembly by disrupting ER-mitochondria contacts.
Not available
S-EPMC12550048 | biostudies-literature
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