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TranscriptomicsCohesin is a key determinant of interphase chromosome domain architecture (HiC)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-49017 | biostudies-arrayexpress
TranscriptomicsThe Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficie...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20352 | biostudies-arrayexpress
GenomicsCohesin is a key determinant of interphase chromosome domain architecture (ChIP-seq)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-48938 | biostudies-arrayexpress
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