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MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6483 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6486 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6485 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 cells treated with ErbB receptor ligands EGF and heregulin at multiple doses and sampled at multiple time points reveals signal transduction pathways devotedly convey quantitative properties of the dose-dependent activation of ErbB receptor to early transcription
ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-dependent transient and sustained intracellular signaling, proliferation and differentiation of MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell determination mechanism, w...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6462 | biostudies-arrayexpress
TranscriptomicsControlled ErbB receptor dimerization
In order to better understand signaling events following receptor dimerization involving HER2, we have generated an experimental system in which ErbB dimerization can be controlled. We used gene expression microarrays to identify genes and pathways that are differentially activated by HER2 homodimer...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22288 | biostudies-arrayexpress
ModelsChen2009 - ErbB Signaling
This is A431 IERMv1.0 model described in the article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Doug...
2024-09-02 | BIOMD0000000255 | BioModels
ProteomicsPhosphoproteomic analysis reveals the diversity of signaling behind ErbB inhibitor-induced phenotypes
Effects of kinase inhibitors on the phosphoproteome have been rarely investigated at a whole organism level. Here we performed a phosphoproteomic analysis in embryonic zebrafish to identify the signaling pathways perturbed by the ErbB receptor tyrosine kinase inhibitors at the whole organism level. ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-12-29 | PXD050396 | Pride
Erbb inhibitor Signaling pathways Zebrafish embryos Phosphoproteome 
ProteomicsThe ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the culprit molecular underpinnings, we designed an approach that combines sensitivity to drugs with an integrated systems-biology characterization. Sensitivity to ...
ORGANISM(S): Sarcophilus harrisii 
2019-01-18 | PXD009283 | Pride
Tasmanian devil Dftd Transmissible cancer Erbb 
GenomicsImpact of ERBB inhibitors on erythroid progenitors
Impact of ERBB inhibitors on erythroid progenitors
PRJNA422526 | ENA
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