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Gene expression analysis in control and diabetic rats. Diabetes-induced erectile dysfunction in rat model of DM. 10 weeks of streptozotocin induced diabetes. F344 Rats.
ORGANISM(S): Rattus norvegicus 
(Erectile dysfunction) ED during the radical prostatectomy (RP) treatment is caused by surgical injury of the cavernous nerve which is the final neuronal pathways of penile erection. We performed microarray experiment focused on theto understanding the gene signature alteration in the corporal caver...
ORGANISM(S): Rattus norvegicus 
The Role of Mechanoregulated YAP/TAZ in Erectile Dysfunction
Phosphodiesterase type 5 inhibitors (PDE5is) are the primary therapeutic option for erectile dysfunction. However, 30% of patients do not respond to PDE5is treatment, making the quest for a new treatment modality a central endeavor. Here, we found a new pathway in erectile function control, mechano-...
ORGANISM(S): Mus musculus Rattus norvegicus 
2023-03-31 | GSE208293 | GEO
Genomics
Gut microbiota in erectile dysfunction
hPSC-derived sacral neural crest cells restore erectile function in pelvic ganglia injury
Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorates erectile dysfunction through Lipocalin 2 in the diabetic mice
Neurovascular dysfunction in penis is a fundamental reason of erectile dysfunction. Diabetes mellitus is one of the major causes of erectile dysfunction and leads to a poor response to oral phosphodiesterase-5 inhibitors. Heat shock protein 70 (Hsp70), a ubiquitous molecular chaperone exist in all l...
ORGANISM(S): Mus musculus 
2022-05-11 | GSE180916 | GEO
Cystathionine gamma-lyase is required for the heat shock protein 70-driven penile neurovascular regeneration and erectile function recovery
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