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TranscriptomicsTranscription profiling of mouse cancer associated fibroblasts (CAFs) reveals are activation in incipient neoplasia to orchestrate tumor promoting inflammation in an NF-I?B-dependent manner.
Full title: Cancer Associated Fibroblasts are activated in incipient neoplasia to orchestrate tumor promoting inflammation in an NF-κB-dependent manner. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion. We demonstrate th...
ORGANISM(S): Mus musculus 
2009-09-13 | E-GEOD-17817 | biostudies-arrayexpress
GenomicsComprehensive mapping of long-range interactions reveals folding principles of the human genome.
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1Mb. These maps confirm the presence of chromosom...
ORGANISM(S): Homo sapiens 
2009-10-09 | E-GEOD-18199 | biostudies-arrayexpress
TranscriptomicsThe metastatic microenvironment. Brain-derived soluble factors alter the malignancy phenotype of cutaneous and brain- metastasizing melanoma cells
The present study deals with functional interactions of cutaneous and brain-metastasizing human melanoma cells with brain-derived molecules. In this study we employed the unique melanoma xenograft model developed by Izraely and described in Int J Cancer. 2011 Oct 25. doi: 10.1002/ijc.27324. The pres...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-34970 | biostudies-arrayexpress
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