Sort   by:  
 Page size 
TranscriptomicsThe effect of ERG overexpression and ERG knockdown by shRNA in RWPE1 and VCAP cells, respectively
The goal of this project was to analyze the global gene expression profiles of RWPE1 and VCAP cells following transfection of GFP, GFP-ERG at 48 and 72hrs time points and stable ERG shRNA, scramble shRNA, respectively. RWPE1 cells were transfected with GFP or GFP-ERG. VCAP cells were transfected wit...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-16671 | biostudies-arrayexpress
GenomicsGenome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia
Here we show that pan-haematopoietic ERG expression driven by the Vav promoter induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene expression and ERG binding profiles revealed that ERG activates a transcriptional program similar to human AML stem...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-46554 | biostudies-arrayexpress
TranscriptomicsERG induced mesenchymal like gene signature
ERG overexpression was conducted in stably transfected K562 cell line with a tet-on inducible plasmid habouring ERG3. Prolonged induction of ERG (8 days) produced spindle cell shape changes whereas non-induced cells retained the round morphology. In oder to determine the genes responsible for induci...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51258 | biostudies-arrayexpress
TranscriptomicsCo-expression of genes with ERG in prostate cancer cell lines
ERG overexpression is the most frequent molecular alteration in prostate cancer. We analyzed different stages of prostate cancer to identify genes that were coexpressed with ERG overexpression. In primary prostate tumors, it was shown that TDRD1 expression was the strongest correlated gene with ERG ...
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-41407 | biostudies-arrayexpress
TranscriptomicsCo-expression of genes with ERG in prostate cancers
ERG overexpression is the most frequent molecular alteration in prostate cancer. We analyzed different stages of prostate cancer to identify genes that were coexpressed with ERG overexpression. In primary prostate tumors, it was shown that TDRD1 expression was the strongest correlated gene with ERG ...
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-41408 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Human Umbilical Vein Endothelial Cells (HUVEC) after treatment with Erg or control antisense (GeneBloc)
The endothelial transcription factor Erg (Ets Related Gene) plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates endothelial cell migration. Transcriptome profiling of Erg-deficient...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-32984 | biostudies-arrayexpress
ProteomicsERG overexpression is a predictive biomarker for PARP-inhibitor-mediated selective radiosensitization in prostate cancer – a proof of concept study
Radiotherapy (RT) is a key treatment for prostate cancer (PCa), relying on the ability to induce DNA damage, particularly double-strand breaks (DSBs). The success of RT depends on tumor radiosensitivity and the ability to repair DSBs, making inhibitors of DSB repair enzymes a potential strategy for ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD060964 | Pride
Prostate cancer Erg overexpression Parp inhibition Dna double-strand break repair Radiotherapy 
TranscriptomicsERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were decreased in these mice. To define Erg downstream target genes in hematopoietic stem cells, we sorted...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-69873 | biostudies-arrayexpress
TranscriptomicsETS2, ERG promote megakaryopoiesis, synergize with alterations in GATA1 to immortalize hematopoietic progenitor cells
Serial replated GFP + lineage negative cells from Gata1deltaneodeltaHS fetal liver hematopoietic progenitors for 4 generations in methocult M3234 under megakaryocyte promoting conditions, IL3, TPO, IL6, and IL11. Cells were subject to retro-viral infection with MIGR1GFP, MIGR1ETS2, MIGR1ERG, and MIG...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-14506 | biostudies-arrayexpress
TranscriptomicsExpression data of leukemia samples taken from transgenic ERG mice
The Ets transcription factor, ERG, plays a central role in definitive hematopoiesis and its overexpression in acute myeloid leukemia is associated with a stem cell signature and bad prognosis. However, little is known about the underlying mechanism by which ERG causes leukemia. Therefore we sought t...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-49787 | biostudies-arrayexpress
Sort   by:  
 Page size