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ProteomicsEukaryotic translation is modulated by natural mRNA nucleotide derivatives
RNA modifications are crucial factors for efficient protein synthesis. All classes of RNAs that are involved in translation are modified to different extents. Recently, mRNA modifications and their impact on gene regulation became a focus of interest because they can exert a variety of effects on th...
ORGANISM(S): Homo sapiens (Human) 
2019-01-30 | PXD011860 | Pride
Translation elongation Ribosome Decoding Biological Nucleotide modifications 
ProteomicsTranslation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bact...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD011301 | Pride
Translation elongation Ribosome Decoding Codon-anticodon interactions Biological Nucleotide modifications 
ProteomicsTranslation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bact...
ORGANISM(S): Escherichia coli 
2018-11-21 | PXD011311 | Pride
Translation elongation Ribosome Decoding Codon-anticodon interactions Biological Nucleotide modifications 
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