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TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44964 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases [MAF siRNA]
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-61964 | biostudies-arrayexpress
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