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Gp130 receptor engagement on neoplastic cells provides a link by which an inflammatory microenvironment facilitates tumour promotion. Although hyperactivation of the gp130-dependent Stat3 signalling node is commonly observed in solid tumours, Stat3 remains a challenging therapeutic target. To mimic ...
ORGANISM(S): Mus musculus 
Chemoreception is based on the senses of smell and taste that are crucial for animals to find new food sources, shelter, and mates. The initial step in olfaction involves the translocation of odorants from the periphery through the aqueous lymph of the olfactory sensilla to the odorant receptors by ...
ORGANISM(S): Tribolium castaneum 

Identifying metabolomes with greater coverage and confidence is a critical step towards interpreting the metabolic basis of human and environmental health. Yet for over two decades the field of metabolomics has been inhibited by limited metabolite identification. To address this, we developed the...

Data from ProteomeXchange, PXD ID: PXD000780. Experiment: O2_U1_gmr_sh_11_1, file: 100223_O2_U1_gmr_sh_11_1_4.mzml. Published as part of J Biotechnol. 2014 Dec 20;192 Pt A:204-14 . From the Abstract: {{i}} Members of the species Bacillus pumilus get more and more in focus of the biotechnological in...
ORGANISM(S): Crap, Bacillus_pumilus_safr_032 
Tetrahydrobiopterin compounds prolong allograft survival independent of their effect on nitric oxide synthase activity
ORGANISM(S): Mus musculus 
Ravindra Garde, Bashar Ibrahim & Stefan Schuster. Extending the minimal model of metabolic oscillations in Bacillus subtilis biofilms. Scientific Reports 10, 1 (2020). Biofilms are composed of microorganisms attached to a solid surface or floating on top of a liquid surface. They pose challenges in...
2024-09-02 | BIOMD0000001053 | BioModels
DNA copy-number profiling of 66 astrocytomas of WHO °I or °II Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy...
ORGANISM(S): Homo sapiens 
Resistance formation is one of the major hurdles in cancer therapy. Metronomic anti-angiogenic treatment of xenografted prostate cancer tumors in SCID mice with cyclophosphamide (CPA) results in the appearance of resistant tumors. To investigate the complex molecular changes occurring during resista...
ORGANISM(S): Homo sapiens 
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