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TranscriptomicsComparison of undifferentiated ES cell lines HM1, IMT11, SHBL6.3
3 different ES cell lines were compared in order to determine whether there are significant expression profile differences between ES cell lines, or whether the constraints of maintaining pluripotency in culture force a similar expression profile on cell lines derived from disparate sources. Our res...
ORGANISM(S): Mus musculus 
2007-08-03 | E-GEOD-8625 | biostudies-arrayexpress
GenomicsCHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Gene expression changes were measured between mouse ES cells of three genotypes: WT Chd7, Heterzygous Chd7 Null, Homozygous Chd7 Null. The hypothesis being tested was that CHD7, a chromatin remodeling protein, functions as a transcriptional regulator. This experiment was performed to detect gene t...
ORGANISM(S): Mus musculus 
2010-06-15 | E-GEOD-22341 | biostudies-arrayexpress
GenomicsThiovulum sp. ES strain:ES
Thiovulum sp. ES strain:ES Genome sequencing and assembly
PRJNA161651 | ENA
GenomicsSetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES cells are less well understood. A high-throughput shRNA screen was used to identify novel chromatin regulators that influence ES cell state...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-18371 | biostudies-arrayexpress
GenomicsMus musculus strain:es
Mus musculus strain:es
PRJNA74767 | ENA
TranscriptomicsHeparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State
Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals ...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15974 | biostudies-arrayexpress
GenomicsmRNA profiling of Pontin depleted ES cells and Oct4 depleted ES cells
mRNA profiling of Pontin depleted ES cells and Oct4 depleted ES cells
PRJEB4779 | ENA
TranscriptomicsDifferential roles of Sall4 isoforms in ES cell pluripotency
This SuperSeries is composed of the following subset Series: GSE21054: Differential roles of Sall4 isoforms in ES cell pluripotency: expression GSE21055: Differential Role of Sall4 isoforms in ES cell pluripotency: ChIP-chip Refer to individual Series
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21056 | biostudies-arrayexpress
GenomicsPRSS1 gene mutated mouse ES cells
PRSS1 gene mutated mouse ES cells
PRJNA488352 | ENA
TranscriptomicsExpression profile of Sall4-null ES cells and Sall4 heterozygous ES cells
Sall4 is a mouse homolog of a causative gene of the autosomal dominant disorder known as Okihiro syndrome. We previously showed that Sall4 absence leads to lethality during peri-implantation and that Sall4-null embryonic stem (ES) cells proliferate poorly with intact pluripotency when cultured on fe...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-14219 | biostudies-arrayexpress
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