Esophageal squamous cell carcinoma

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Unknown (3613)
Genomics (631)
Transcriptomics (398)
Proteomics (61)
Clinical (60)
Methylation profiling (25)
Metabolomics (8)
Other (4)
Genomic (1)

Organisms

Homo sapiens (534)
Mus musculus (39)
Andropogon gerardi (21)
Bacteria (21)
Canis lupus familiaris (21)
Clavibacter nebraskensis NCPPB 2581 (21)
Rattus norvegicus (6)
synthetic construct (6)
Betapolyomavirus hominis (2)
Betapolyomavirus macacae (2)
Human alphaherpesvirus 1 (2)
Human immunodeficiency virus 1 (2)
JC polyomavirus (2)
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 (1)
Bifidobacterium breve UCC2003 (1)
Listeria monocytogenes (1)
Porphyromonas gingivalis (1)
Oncorhynchus mykiss (1)
Cytomegalovirus (1)
Human alphaherpesvirus 2 (1)
Human betaherpesvirus 5 (1)
Human gammaherpesvirus 8 (1)
Lymphocryptovirus (1)
Merkel cell polyomavirus (1)
Murid betaherpesvirus 1 (1)
Murid gammaherpesvirus 4 (1)
Rhadinovirus (1)
human gammaherpesvirus 4 (1)
solid waste metagenome (1)
unidentified (1)

Organisms

Homo sapiens (374)
Mus musculus (21)
Mus (2)
unidentified (2)
Porphyromonas gingivalis (1)
human oral metagenome (1)
human metagenome (1)

Repository

ENA (512)
geo (355)
biostudies-arrayexpress (152)
iProX (38)
EGA (31)
pride (21)
MetaboLights (8)
ExpressionAtlas (7)
MassIVE (2)
dbGaP (1)
EVA (1)

Tissue

Esophagus (6)
Brain (4)
Breast (3)
Kidney (3)
Large intestine (3)
Liver (3)
Lung (3)
Ovary (3)
Pancreas (3)
Prostate gland (3)
Skin (3)
Stomach (3)
Thyroid gland (3)
Urinary bladder (3)
Uterine cervix (3)
Uterus (3)
Blood (2)
Mouth mucosa (2)
Skeletal muscle tissue (2)
Adrenal gland (1)
Bile duct (1)
Bone (1)
Connective tissue (1)
Gall bladder (1)
Hematopoietic system (1)
Mucosa (1)
Musculature (1)
Peripheral nervous system (1)
Placenta (1)
Testis (1)

Disease

Bladder transitional cell carcinoma (4)
Breast adenocarcinoma (4)
Cervical squamous cell carcinoma (4)
Cholangiocarcinoma (4)
Esophageal adenocarcinoma (4)
Follicular thyroid carcinoma (4)
Gastric adenocarcinoma (4)
Head and neck squamous cell carcinoma (4)
Hepatocellular carcinoma (4)
Invasive lobular carcinoma (4)
Lung adenocarcinoma (4)
Melanoma (4)
Ovarian adenocarcinoma (4)
Pancreatic adenocarcinoma (4)
Renal cell carcinoma (4)
Squamous cell lung carcinoma (4)
Cervical adenocarcinoma (3)
Chronic lymphocytic leukemia (3)
Colorectal adenocarcinoma (3)
Endometrial adenocarcinoma (3)
Esophageal squamous cell carcinoma (3)
Glioblastoma multiforme (3)
Glioma (3)
Lymphoma (3)
Prostate adenocarcinoma (3)
Sarcoma (3)
Askin tumor (2)
B-cell acute lymphoblastic leukemia (2)
B-cell non-Hodgkin lymphoma (2)
Burkitts lymphoma (2)

Technology Type

Mass Spectrometry (21)
Shotgun proteomics (11)
Mass spectrometry (7)
Illumina HiSeq 2000 (4)
Bottom-up proteomics (3)
Affinity purification coupled with mass spectrometry proteomics (2)
Data-independent acquisition (2)
SWATH MS (2)
Illumina HiSeq 2000, ILLUMINA (1)
Mass spectrometry assay (1)
Gel-based experiment (1)
Top-down proteomics (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - positive - reverse phase (2)
Unix (1)
Scanning hardware (1)
NextSeq 550 (1)
Illumina HiSeq 2500 (1)
Illumina NovaSeq 6000 (1)
NextSeq 500 (1)
Illumina Hiseq Xten (1)
Q Exactive (1)
TripleTOF 6600 (1)
Gas Chromatography MS - positive (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - Negative (LC-MS (Negative)) (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2024 (55)
2014 (50)
2016 (49)
2025 (44)
2026 (43)
2023 (42)
2021 (35)
2022 (30)
2011 (28)
2010 (28)
2020 (28)
2018 (23)
2013 (22)
2015 (21)
2019 (14)
2017 (12)
2012 (12)
2008 (10)
2009 (6)
2007 (4)
2006 (3)
2005 (2)

CHEBI ID

CHEBI:55328 (3)
CHEBI:17158 (2)
CHEBI:41321 (2)
CHEBI:28123 (2)
CHEBI:75550 (2)
CHEBI:78737 (2)
CHEBI:17151 (2)
CHEBI:15753 (2)
CHEBI:16914 (2)
CHEBI:27410 (2)
CHEBI:37998 (2)
CHEBI:73134 (2)
CHEBI:28875 (2)
CHEBI:30805 (2)
CHEBI:16828 (2)
CHEBI:7916 (2)
CHEBI:15756 (2)
CHEBI:16857 (2)
CHEBI:15971 (2)
CHEBI:17405 (2)
CHEBI:16016 (2)
CHEBI:17295 (2)
CHEBI:17752 (2)
CHEBI:27248 (2)
CHEBI:17568 (2)
CHEBI:17895 (2)
CHEBI:16335 (2)
CHEBI:180915 (1)
CHEBI:194570 (1)
CHEBI:194568 (1)

Metabolite Name

Gamma-Linolenic acid (2)
Pyruvaldehyde (2)
Urocanic acid (2)
4-Pyridoxic acid (2)
Diethanolamine (2)
Betaine (2)
L-Threonine (2)
Palmitic acid (2)
L-Phenylalanine (2)
L-Tyrosine (2)
Adenosine (2)
Beta-Octylglucoside (1)
3-Aminobenzoic acid (1)
LPA(18:2/0:0) (1)
PI(16:0/18:3) (1)
PI(22:5/16:0) (1)
2-(6-hydroxy-6-methyloctyl)-2H-furan-5-one (1)
[3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(4Z,7Z)-octadeca-4,7-dienoyl]oxypropyl] octadecanoate (1)
PS(P-18:0/12:0) (1)
2-(1-Methylpropyl)-4,6-dinitrophenol (1)
LPG(16:0/0:0) (1)
TMC-1D (1)
LPA(20:0/0:0) (1)
M3 3-Phosphoglycerate (1)
M2 3-Phosphoglycerate (1)
M1 3-Phosphoglycerate (1)
M0 3-Phosphoglycerate (1)
M6 Citrate (1)
M5 Citrate (1)
M4 Citrate (1)

First Public Date

2024 (80)
2026 (62)
2014 (59)
2025 (54)
2023 (50)
2021 (41)
2022 (40)
2020 (36)
2018 (27)
2017 (19)
2016 (16)
2019 (14)
2015 (11)
2013 (3)

Classification

bacteria (1)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study status

Recruiting (26)
Completed (13)
Active, not recruiting (11)
Not provided (5)
Withdrawn (2)
Terminated (2)
Not yet recruiting (1)

Study type

Transcription profiling by array (110)
Interventional (56)
Comparative genomic hybridization by array (10)
RNA-seq of coding RNA (10)
Methylation profiling by array (8)
Unknown experiment type (5)
Observational (4)
RNAi profiling by array (2)
Other (2)
RNA-seq of non coding RNA (2)
Transcription profiling by SAGE (1)
ChIP-seq (1)
MicroRNA profiling by array (1)

Release Date

2022 (492)
2025 (443)
2021 (435)
2023 (409)
2024 (404)
2020 (330)
2019 (196)
2017 (188)
2018 (168)
2016 (156)
2014 (121)
2015 (119)
2026 (76)
2013 (71)
2011 (47)
2010 (39)
2012 (32)
2009 (13)
2008 (12)
2007 (4)
2006 (4)
2002 (2)
2005 (1)
2004 (1)
1998 (1)
1997 (1)

Lab affiliation

Institute of Bioinformatics , International Technology Park, Bangalore, India (2)
The Fifth Affiliated Hospital of Guangzhou Medical University (2)
BGI-Shenzhen,China (1)
Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China (1)
Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, China. (1)
Department of Thoracic Surgery and Lung Transplantation, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China (1)
Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA (1)
Harsha Gowda, Institute of Bioinformatics, Discoverer, 7th floor, International tech park, whitefield road, Bengaluru. 560066 (1)
Institute of Bioinformatics, 7th floor, Discoverer Building, International Tech Park, Bangalore, 560 066, India (1)
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India (1)
MOE Key Laboratory of Tumor Molecular Biology and State Key Laboratory of Bioactive Molecules and Druggability Assessment, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China. (1)
Qilu Hospital of Shandong University (1)
SAMRC Gynaecology Cancer Research Centre, University of Cape Town, South Africa (1)
The Fifth Affiliated Hospital of Guangzhou Medical University, China (1)
Univeristy of California, San Francisco (1)
Xiamen University (1)
Zhao Lab, School of Life Science, Fudan University, Shanghai, China (1)
Zhengzhou university (1)
changzhi medical college (1)

Location

United States (40)
China (9)
Spain (9)
Canada (8)
Australia (7)
Japan (6)
Italy (6)
France (6)
Germany (5)
South Korea (5)
Chile (4)
Netherlands (4)
United Kingdom (4)
Belgium (4)
Israel (3)
Brazil (3)
Hong Kong (2)
Taiwan (2)
Singapore (2)
Denmark (2)
Turkey (2)
Russia (2)
Poland (2)
Argentina (2)
Oceania (1)
Guam (1)
Finland (1)
Ireland (1)
Asia except Japan (1)
Europe (1)

Keyword

Pembrolizumab (12)
Immunotherapy (5)
HNSCC (4)
Nivolumab (4)
CRC (4)
RCC (3)
SCCHN (3)
Spartalizumab (3)
Trastuzumab (3)
Antibodies, Monoclonal (3)
Bevacizumab (3)
Cetuximab (3)
Src homology phosphatase 2 (SHP2) (2)
Kirsten rat sarcoma (KRAS) proto-oncogene, GTPase (2)
Epidermal growth factor receptor (EGFR) (2)
GEJ (2)
Lenvatinib (2)
HCC (2)
PTPN11 (2)
TNBC (2)
Docetaxel (2)
Carboplatin (2)
Erlotinib Hydrochloride (2)
Interleukin-2 (2)
IL-2 (2)
Tislelizumab (2)
Ipilimumab (2)
Metastatic (2)
HER2 (2)
Antineoplastic Agents, Immunological (2)

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SOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights

Identification of a Novel Angiogenesis and Tumor Suppressor Gene Rab25 in Esophageal Squamous Cell Carcinoma

Twelve clinical samples from human esophageal squamous cell carcinoma (ESCC) (seven tumors and five non-tumors) were sequenced using Illumina high-throughput sequencing and the RNA-Seq profiling was investigated with 1730 genes significantly differentially expressed. The gene Rab25 was found to be d...

ORGANISM(S): Homo sapiens

2012-12-05 | E-GEOD-32424 | biostudies-arrayexpress

Analysis of genomic instability in esophageal squamous cell carcinoma (ESCC)

To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...

ORGANISM(S): Homo sapiens

2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress

Gene expression signatures and pathway analysis of esophageal squamous cell carcinoma

We identified a number of deregulated genes through transcriptome analysis on esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues. Our pathway enrichment analysis suggested that deregulated genes were strongly enriched in multiple functionally linked pathways known to be important ...

ORGANISM(S): Homo sapiens

2016-07-24 | E-GEOD-77531 | biostudies-arrayexpress

Methylation profiles of esophageal squamous cell carcinoma patients and cancer-free individual in Taiwan.

Genome wide DNA methylation profiling of tumor and normal samples with esophageal squamous cell carcinoma patients. The Illumina GolodenGate methylation cancer panel I was used to obtain DNA methylation profiles across approximately 1,505 CpGs in esophageal squemous cell carcinoma samples. Samples i...

ORGANISM(S): Homo sapiens

2014-09-11 | E-GEOD-51287 | biostudies-arrayexpress

the whole-genome methylation profile of esophageal squamous cell carcinoma

Both genetic and epigenetic aberrations are linked by intricate crosstalk, and can either individually or in synergy lead to the development of cancer. Accumulating evidence suggests that epigenetic changes such as alterations in DNA methylation play a crucial role in ESCC. We performed a Illumina I...

ORGANISM(S): Homo sapiens

2014-11-03 | E-GEOD-52826 | biostudies-arrayexpress

Identification of a methylome signature of esophageal squamous cell carcinoma

Background & Aims: Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation is a critical epigenetic mechanism involved in key cellular processes and its deregulation has been linked to many hum...

ORGANISM(S): Homo sapiens

2011-11-23 | E-GEOD-26784 | biostudies-arrayexpress

Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma

We have investigated expressed microRNA in cryo-preserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses reveal a unique microRNA expression signature composed of 40 genes which can distinguish normal from malignant esophageal tissue. Some microRNA...

ORGANISM(S): Homo sapiens

2010-05-26 | E-GEOD-6188 | biostudies-arrayexpress

Paired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients

Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and...

ORGANISM(S): Homo sapiens

2010-07-09 | E-GEOD-13937 | biostudies-arrayexpress

Analysis of gene expression in esophageal squamous cell carcinoma (ESCC)

To characterize gene expression in esophageal squamous cell carcinoma, we examined gene expression in tumor and matched normal adjacent tissue from 17 ESCC patients from a high-risk region of China. RNA was extracted from 17 micro-dissected tumor and matched normal tissue pairs using the PureLink Mi...

ORGANISM(S): Homo sapiens

2011-03-15 | E-GEOD-20347 | biostudies-arrayexpress

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