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Transcriptomicsthe influence of a modification of the gut microbiota composition on the hepatic steatosis induced by n-3 polyunsaturated fatty acid (PUFA) depletion
in the present study, we evaluated whether microbiota modulation is able to restore hepatic steatosis induced by n-3 PUFA depletion in mice. For this purpose, mice were fed during three months with a n-3 PUFA-depleted diet (presenting a high n-6/n-3 PUFA ratio), and then supplemented with fructoolig...
ORGANISM(S): Mus musculus 
2012-12-12 | E-GEOD-31727 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of imatinib-treated and untreated human Hematopoetic progenitors expressing the ETV6-PDGFRB oncogene
In order to investigate the mechanism whereby TEL-PDGF-beta (ETV6-PDGFRB) interferes with human hematopoietic progenitors proliferation and differentiation, we analyzed the gene expression response downstream this oncogene. CD34+ cells infected with lentivirus coding for TEL-PDGFRb were cultured for...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-28698 | biostudies-arrayexpress
TranscriptomicsThe consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice
In the present study, we investigated the consequences of n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic lipid metabolism in mice fed during three months with a diet presenting a high n-6/n-3 PUFA ratio to induce n-3 PUFA depletion. Microarray analyses were performed to identify the mol...
ORGANISM(S): Mus musculus 
2011-08-25 | E-GEOD-26986 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues ...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-24358 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation)
We compared the gene expression profiles of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation). Cells grown in the presence of FGF-2 were used as a reference.
ORGANISM(S): Rattus norvegicus 
2006-03-15 | E-TABM-39 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-33568 | biostudies-arrayexpress
TranscriptomicsGene expression profiling from pooled samples of subcutaneous adipose tissue of NAPE-WT or NAPE-KO mice fed either with a control diet or a high-fat diet.
Mice knocked-out or wild type for the NAPE PLD gene specifically in adipose tissue, were recruited for this expression profiling experiment. Each group of mice (WT versus cKO) were fed with a control diet or a high fat diet. Then mice were sacrificed and adipose tissue samples form the subcutaneous ...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-56852 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
Gene expression profiles of primary neuroendocrine tumors treated or not with 1µM Octreotide.We investigated 5 human neuroendocrine cell lines, CNDT2.5 and KRJ1, established from ileum NETs, QGP1 by a pancreatic NET, NCI H720 and NCI H727 from bronchopulmonary NETs. CNDT2.5 cell wereconstantly treat...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-MTAB-388 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-MTAB-862 | biostudies-arrayexpress
TranscriptomicsBa/F3 cells expressing ETV6-PDGFRb and FIP1L1-PDGFRa treated or not with Glivec
Gene expression profiles in Ba/F3 cells expressing ETV6-PDGFRB, FIP1L1-PDGFRA or a control vector, treated or not with imatinib (Glivec) Ba/F3 cells expressing FIP1L1-PDGFRA or ETV6-PDGFRB were cultured in the presence or absence of imatinib for 4 hours before RNA extraction followed by hybridizatio...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-44810 | biostudies-arrayexpress
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