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MetabolomicsEffect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Antibiotics were once used in animal production to improve productivity and resistance to pathogenic microbiota. However, due to its negative effects, the search for a new class of substances that can replace its efficacy has become one of the urgent problems to be solved. Plant essential oils (E...

2022-09-13 | MTBLS3683 | MetaboLights
MetabolomicsOregano essential oil-driven rumen microbiome metabolism potentially regulates intramuscular fatty acid profile in Holstein bulls through liver lipid metabolism

Abstract

Background

While oregano essential oil (OEO) has been used as a feed additive in ruminant production and shown to positively influence meat quality, its effects on the rumen microbiota and host liver metabolism, and the potential mechanisms linking these to intramuscular fat...

2025-12-15 | MTBLS13490 | MetaboLights
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
GenomicsTraDIS-Xpress identifies essential genes for Salmonella survival following combined heat and essential oil treatments in planktonic cultures and established biofilms
We used TraDIS-Xpress (a high throughput next generation TnSeq approach) to determine the essential genes required for survival of Salmonella in simulated decontamination protocols using heat treatment and essential oil preparations. We exposed planktonic cultures and established biofilms in paralle...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2026-10-05 | E-MTAB-17304 | biostudies-arrayexpress
ProteomicsGenes essential for phototrophic growth by a purple alphaproteobacterium
We identified 171 genes required for growth in this condition, 35 of which are annotated as photosynthesis genes. As a complement to the genetic data, we carried out proteomics experiments in which we found that 429 proteins were present in significantly higher amounts in cells grown anaerobically i...
ORGANISM(S): Rhodopseudomonas palustris 
2017-07-11 | PXD006084 | Pride
Photosynthesis Bacteria Essential genes 
GenomicsAmplicon sequencing data of sgRNA cassettes from pig CRISPR screening time course to identify essential genes in PK15 and IPEC-J2 cell lines
This study describes a genome-wide CRISPR-Cas9 knockout (GeCKO) screen performed in two porcine cell lines, PK15 and IPEC-J2. A custom-designed porcine GeCKO (pGeCKO) library targeting protein-coding genes, lncRNAs, and miRNAs was used. Genomic DNA was harvested from GeCKO cell populations at four t...
ORGANISM(S): Salmo salar 
2025-08-30 | E-MTAB-15487 | biostudies-arrayexpress
GenomicsTranscription Analysis of Clustered Essential Genes
Transcription Analysis of Clustered Essential Genes
PRJNA612782 | ENA
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (ChIP)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30989 | biostudies-arrayexpress
TranscriptomicsThe kinase TNIK is an essential activator of Wnt target genes
Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/ß-catenin activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/ß-catenin transcriptional progra...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17623 | biostudies-arrayexpress
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