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TranscriptomicsTranscription profiling of mouse Langerhans cells from aryl hydrocarbon receptor deficient mice
The arylhydrocarbon receptor is a ligand inducible transcription factor. Known to control xenobiotic metabolizing enzymes, it also affects - depending on the cell type - numerous other genes, either directly or indirectly. With respect to the immune system, persistent activation leads to immunosuppr...
ORGANISM(S): Mus musculus 
2009-11-16 | E-GEOD-13130 | biostudies-arrayexpress
TranscriptomicsEffect of an AhR-/- on transcription in CD4 T cells from the spleen.
CD4+ T cells from 8-12 week female mice were isolated from wt and AhR-/- mice 24h after injection of 10µg/kg TCDD or solvent control. Keywords: TCDD, AHR, immunosuppression Each experiment was performed in biological duplicates from 4 pooled animals. Since TCDD treatment showed only marginal impac...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10084 | biostudies-arrayexpress
TranscriptomicsTCDD induced gene expression changes in dendritic cells
Effect of the over activation of the aryl hydrocarbon receptor on gene expression of spleen derived dendritic cells. 8-12 week old, female C57BL6 mice were injected 10 µg/kg TCDD i.p. or solvent control. After 24 h mice were sacrificed and splenic dendritic cells purified by MACS sorting.
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-13719 | biostudies-arrayexpress
TranscriptomicsRole of AhR in thymocyte emigration in vivo
Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the p...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress
TranscriptomicsAHR mediated gene expression changes in immature DN thymocytes and thymic emigrants
Effect of an immunosupressive dose of TCDD, a ligand for the aryl hydrocarbon receptor, on the gene expression profile of fetal DN thymocytes and thymic emigrants C57BL6 mice were mated and the pregnant dams sacrifice at day 15 of gestation. Fetal thymic lobes were prepared and cultured for 6 days o...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-13720 | biostudies-arrayexpress
TranscriptomicsAhR activation by TCDD in the ET, cortical epithelial cell line
Over activation of the aryl hydrocarbon receptor (AhR) by TCDD results ampng other phenotypes in severe thymic atrophy accompanied by immunosuppression. The link between thymic atrophy, skewed thymocyte differntiation and immunosuppression is still not fully resolved. This study investigates the TCD...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-10168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HL-60 leukemia cells after treatment with Curcumin and TCDD
Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-16160 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Primary Langerhans cells in animals treated with TCDD
The transcriptome of murine LC after 24 hours in vivo exposure to a moderate dose of 10 microgram 2,3,7,8-tetrachlorodibenzo-p-dioxin was studied. It was found that mice, although they express the arylhydrocarbon receptor abundantly in LC, are inert to its activation. Target genes are not inducible,...
ORGANISM(S): Mus musculus 
2009-05-11 | E-GEOD-9506 | biostudies-arrayexpress
TranscriptomicsExpression data of primary melanocytes from aryl hydrocarbon deficient mice and corresponding wild-type C57BL/6 mice
[original Title] Comparison of expression data of primary murine melanocytes from aryl hydrocarbon deficient mice and corresponding wild-type C57BL/6 mice Melanin is produced exclusively by melanocytes and melanogenesis is the vital response to protect skin cells against Ultraviolet B (UVB)-induced...
ORGANISM(S): Mus musculus 
2010-09-05 | E-GEOD-19411 | biostudies-arrayexpress
TranscriptomicsRole of Blimp-1 in programing Th effector cells into IL-10 producers
Gene expression profiling on IL-10-secreting and non-secreting murine Th1 cells, stimulated in the presence or absence of the Notch ligand Delta-like 4 (Dll4), was performed to identify transcription factors co-expressed with IL-10. Primary naM-CM-/ve T helper cells were isolated from lymph nodes an...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57417 | biostudies-arrayexpress
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