Sort   by:  
 Page size 
MetabolomicsExploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not wel...
2025-09-11 | MTBLS5821 | MetaboLights
TranscriptomicsGlobal Analysis of the Immediate Transcriptional Effects of Estrogen Signaling Reveals a Rapid, Extensive, and Transient Response
We report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using Global Run-On and sequencing (GRO-seq). We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. ...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-27463 | biostudies-arrayexpress
TranscriptomicsTranscriptional effect of CRH on MCF7 estrogen receptor signalling
MCF7 cells were stimulated with vehicle or 100nM corticotropin releasing hormone (CRH) for 24h. The effect of CRH on the expression of genes relevant to estrogen signalling was investigated by using the Human Estrogen Receptor Signaling RTM-BM-2 ProfilerM-bM-^DM-" PCR Array (SABioscience Corp). qPCR...
ORGANISM(S): Homo sapiens 
2013-07-02 | E-GEOD-47958 | biostudies-arrayexpress
TranscriptomicsRapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury
Background: Clinical trial and epidemiological data support that the cardiovascular effects of estrogen are complex, including a mixture of both potentially beneficial and harmful effects. In animal models, estrogen protects females from vascular injury and inhibits atherosclerosis. These effects ar...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-35558 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF cells treated with estrogen
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in b...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-11324 | biostudies-arrayexpress
TranscriptomicsGenomics of signalling crosstalk of estrogen receptor alpha in breast cancer cells
The estrogen receptor a (ERa) is a ligand-regulated transcription factor. However, a wide variety of other extracellular signals can activate ERa in the absence of estrogen. The impact of these alternate modes of activation on gene expression profiles has not been characterized. We show that estroge...
ORGANISM(S): Homo sapiens 
2008-05-22 | E-GEOD-10466 | biostudies-arrayexpress
TranscriptomicsPostrecruitment Regulation of RNA Pol II Directs Rapid Signaling Responses at the Promoters of Estrogen Target Genes
Under current models for signal-dependent transcription in eukaryotes, DNA-binding activator proteins regulate the recruitment of RNA polymerase II (Pol II) to a set of target promoters. Yet, recent studies, as well as our results herein, show that Pol II is widely distributed (i.e., "preloaded") a...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-13051 | biostudies-arrayexpress
ProteomicsNuclear Estrogen Receptor alpha (ERα) interactome following estrogen and antiestrogen treatment.
The Estrogen Receptor alpha (ERα) controls key cellular functions in hormone responsive breast cancer by assembling in large functional multiprotein complexes. ERα ligands are classified as agonists and antagonist, according to the response they elicit, thus the molecular characterization of the of ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-02 | PXD018709 | Pride
Estrogen and antiestrogen signaling Interaction proteomics Estrogen receptor alpha (erα) 
TranscriptomicsTranscription profiling of human cancer cell line MCF-7 - estrogen effects where MCF7 is co-expressing ERa and ERb
Two subtypes of the estrogen receptor, ERalpha and ERbeta, mediate the actions of estrogens, and the majority of human breast tumors contain both ERalpha and ERbeta. To examine the possible interactions and modulatory effects of ERbeta on ERalpha activity, we have used adenoviral gene delivery to pr...
ORGANISM(S): Homo sapiens 
2009-04-24 | E-GEOD-4006 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human MCF7 cells with elimination of either TFAP2C or TFAP2A reveals TFAP2C regulates multiple pathways of estrogen signaling
We were interested in determining what genes might be controlled by TFAP2C and/or TFAP2A, either directly or indirectly through regulation of ER-alpha and potentially other signaling pathways. We performed an microarray analysis in MCF7 cells with elimination of either TFAP2C or TFAP2A. The patterns...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8640 | biostudies-arrayexpress
Sort   by:  
 Page size