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UnknownSite-specific N-glycosylation characterization of micro monoclonal immunoglobulins based on EThcD-sceHCD-MS/MS.
Not available
S-EPMC9520751 | biostudies-literature
ProteomicsEThcD-sceHCD-MS/MS-based Clinical N-glycoproteomics
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy collisional dissociation (sceHCD), and higher-ene...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030288 | Pride
Glycoproteomics Mass spectrometry Ethcd-scehcd Fragmentation mode N-glycosylation Clinical sample 
UnknownImproved online LC-MS/MS identification of O-glycosites by EThcD fragmentation, chemoenzymatic reaction, and SPE enrichment.
Not available
S-EPMC8052266 | biostudies-literature
ProteomicsSite-specific N-glycosylation Characterization of Micro Disease-related Proteins Based on EThcD-sceHCD-MS/MS
Monoclonal immunoglobulin produced by clonal plasma cells is the main cause in multiple myeloma and monoclonal gammopathy of renal significance. Because of the complicated purification method and the low stoichiometry of purified protein and glycans, site-specific N-glycosylation characterization fo...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD035757 | Pride
N-glycosylation  microscale  serum  monoclonal immunoglobulin  mass spectrometry  ethcd-scehcd 
UnknownDifferential Quantitative Determination of Site-Specific Intact N-Glycopeptides in Serum Haptoglobin between Hepatocellular Carcinoma and Cirrhosis Using LC-EThcD-MS/MS.
Not available
S-EPMC6465142 | biostudies-literature
ProteomicsO-GlcNac Mapping of WNK4 KLHL3 using LC-MS-EThCD, Boyce Lab Duke Univ
In-gel trypsin digested proteins (WNK4 and KLHL3) subjected to LC-MS/MS on a Fusion Lumos collecting data with a ETHcD bottoms-up proteomics method.
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD055905 | Pride
Glcnac Lumos 
UnknownComprehensive Plasma N-Glycoproteome Profiling Based on EThcD-sceHCD-MS/MS.
Not available
S-EPMC9251008 | biostudies-literature
ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-31 | MSV000085203 | MassIVE
ProteomicsComprehensive human plasma N-glycoproteome profiling based on EThcD-sceHCD-MS/MS
N-glycoproteins are involved in various biological processes. More than one-third of plasma tumor protein biomarkers approved by the Food and Drug Administration (FDA) are glycoproteins which would enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of pla...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030622 | Pride
Mass spectrometry  human plasma  n-glycoproteomics  combinatorial peptide ligands library  ethcd-scehcd 
ProteomicsConjugation site characterization of antibody–drug conjugates using electron-transfer/higher-energy collision dissociation (EThcD)
Antibody–drug conjugates (ADCs) are formed by binding of cytotoxic drugs to monoclonal antibodies (mAbs) through chemical linkers. A comprehensive evaluation of the critical quality attributes (CQAs) of ADCs is vital for drug development but remains challenging owing to ADC structural heterogeneity ...
ORGANISM(S): Homo Sapiens 
2023-02-14 | PXD040111 |
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