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TranscriptomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (Affymetrix)
DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-59586 | biostudies-arrayexpress
UnknownThe Endogenous Retinoic Acid Receptor Pathway Is Exploited by Mycobacterium tuberculosis during Infection, Both In Vitro and In Vivo.
Not available
S-EPMC12462659 | biostudies-literature
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33624 | biostudies-arrayexpress
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 2)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33625 | biostudies-arrayexpress
TranscriptomicsDifferential effects of antofine N-oxide on solid tumor and leukemia cells
We have studied the anti-cancer activities of antofine N-oxide isolated and purified from the medicinal plant Cynanchum vincetoxicum. The compound displays a strong cytotoxic effect on several solid tumor cell lines (glioblastoma, breast carcinoma and lung carcinoma) and on T-cell leukemia. It induc...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-MTAB-1900 | biostudies-arrayexpress
TranscriptomicsTRRAP-mediated regulation of Wee1
The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Up-regulation of Chk1 by mutation or overexpression bypasses the requirement for up-stream regulators or DNA damage to promote a G2 cell cycle arrest. We screened i...
ORGANISM(S): Schizosaccharomyces pombe 
2010-04-11 | E-GEOD-12674 | biostudies-arrayexpress
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
UnknownCardioversion in patients with newly diagnosed non-valvular atrial fibrillation: observational study using prospectively collected registry data.
Not available
S-EPMC8548918 | biostudies-literature
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