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GenomicsMapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST).
ETV1 is highly expressed in GIST and their presumed precursors--the interstitial cells of Cajal. ETV1 is required for survival for both GIST and ICC and regulates GIST signature genes. Here, using Illumina-Solexa based next-generation sequencing of ETV1 chromatin immunoprecipates (ChIP-Seq), we defi...
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-22441 | biostudies-arrayexpress
TranscriptomicsProfiling of RWPE cells stably over-expressing ETV1
RWPE benign prostatic epithelial cells were infected with a lentivirus expressing ETV1 or GUS (control), and stable clones were isolated by puromycin selection. ETV1 over-expression, recapitulating ETS gene rearrangements observed in vivo, confers invasiveness in the benign prostate cell line RWPE. ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-7701 | biostudies-arrayexpress
TranscriptomicsETV1 knockdown in GIST cell lines
ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown. Two GIST cell lines (GIST48 and GIST882) were infected in duplicate with three shRNA virus...
ORGANISM(S): Homo sapiens 
2010-10-13 | E-GEOD-19396 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of murine GIST-like tumors after Etv1 ablation
We used a mouse expressing three alleles 1) KitV558Delta/+ activating allele that develop GIST-like tumors in the cecum, 2) Etv1 flox/flox conditional knockout allele and 3) Rosa26-CreERT2 tamoxifen activated Cre allele. Mice were treated with either Tamoxifen (to delete Etv1) or corn oil (control)....
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-64608 | biostudies-arrayexpress
GenomicsEffect of ETV1 knockdown on genome wide AR binding in LNCaP Cells
Translocation of ETS transcription factors including ERG and ETV1 occur in half of all prostate cancers. LNCaP cells harbor an ETV1 translocation. We performed ChIP-Seq analysis to determine the role of ETV1 on AR binding. The localization of enhancers were determined by H3K4me1 ChIP-Seq. To determi...
ORGANISM(S): Homo sapiens 
2013-06-13 | E-GEOD-47120 | biostudies-arrayexpress
GenomicsETV1 and FOXF1 cistrome in wildtype GIST48, GIST-T1, MDA-PCa2b, and ETV1 or FOXF1 knocked-down GIST48 cells
ETV1 and FOXF1 cistrome in wildtype GIST48, GIST-T1, MDA-PCa2b, and ETV1 or FOXF1 knocked-down GIST48 cells
PRJNA417539 | ENA
GenomicsETV1 ChIP-seq in OE33 esophageal adenocarcinoma cells
Chromatin immunoprecipitation using anti-ETV1 a.k.a. ER81 (Abcam: ab81086) antibodies or input DNA in an OE33 cell line
ORGANISM(S): Homo sapiens 
2017-07-07 | E-MTAB-5168 | biostudies-arrayexpress
GenomicsETV1 ChIP-seq in OE33 esophageal adenocarcinoma cells
ETV1 ChIP-seq in OE33 esophageal adenocarcinoma cells
PRJEB16331 | ENA
TranscriptomicsGene expression profile of ETV1 knockdown in LNCaP prostate cancer cells
Over half of prostate cancer harbor overexpression of ETS transcription factors including ERG and ETV1. LNCaP prostate cancer cells have an ETV1 translocation to the MIPOL1 locus on 14q13.3-13q21.1. To determine genes regulated by ETV1, we performed shRNA mediated knockdown of ETV1 using two lentivi...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-46329 | biostudies-arrayexpress
GenomicsImpact of transcription factor ETV1 on HCT116 colon cancer cells.
Impact of transcription factor ETV1 on HCT116 colon cancer cells.
PRJNA664764 | ENA
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