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TranscriptomicsTranscription profiling of Arabidopsis polysomal and non-polysomal RNA samples isolated from 10-day-old wild-type and eif3h mutant plants
Microarray comparisons of polysome loading in wild-type Arabidopsis and eif3h mutant; Goal: ; To find the target mRNAs that are translationally regulated by eIF3h. BACKGROUND: The eukaryotic translation initiation factor eIF3 has multiple roles during the initiation of translation of cytoplasmic mRN...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6024 | biostudies-arrayexpress
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
TranscriptomicsCharacterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5′ cap status
The mRNA 5′ cap is normally essential for eukaryotic mRNA translation, stabilization and transport and both the cap and eIF4E are important elements of post-transcriptional gene regulation. To further our understanding of mRNA translation in the human malaria parasite Plasmodium falciparum, we hav...
ORGANISM(S): Plasmodium falciparum 
2010-06-10 | E-GEOD-6356 | biostudies-arrayexpress
Transcriptomicseif3k/WT polysome loading
To understand the contribution of the k subunit of eukaryotic transcription factor 3 (eif3k) to the translation of specific mRNAs, we compared the polysome loading states and overall transcript levels of wild type Arabidopsis and the eif3k T-DNA insertion mutant by Affymetrix arrays. We analyzed the...
ORGANISM(S): Arabidopsis thaliana 
2011-03-29 | E-GEOD-28223 | biostudies-arrayexpress
TranscriptomicsThe Translation Initiation Factor eIF3h Targets Specific Transcripts to Polysomes during Embryogenesis
We have sequenced the polysome-associated translating mRNAs from stage-matched wild-type and eif3ha morphant embryos at ~24 hpf stage to identify transcripts translationally regulated by eIF3ha. As a control, we have also sequenced total mRNAs from the stage-matched wild-type and eif3ha morphants as...
ORGANISM(S): Danio rerio 
2013-06-05 | E-GEOD-44584 | biostudies-arrayexpress
TranscriptomicsTranslation State Array Assay for C elegans IFE-1-dependent mRNAs
Relative polysomal loading changes for wild type (N2) versus ife-1(bn127) C. elegans strains Strain ife-1(bn127) is null for the gene encoding one of five eIF4E isoforms in the worm, IFE-1. Only this isoform associates with P granules. Resolution of translating and non-translating mRNAs from WT and...
ORGANISM(S): Caenorhabditis elegans 
2016-01-07 | E-GEOD-74459 | biostudies-arrayexpress
Transcriptomicsm6A in 5’ untranslated regions promotes cap-independent translation of mRNA
N6-methyladenosine (m6A) is a widespread internal RNA modification whose function is poorly understood. Here we report that m6A residues within the 5'UTR promote a novel form of cap-independent translation which is mediated through an interaction between m6A residues and the translation initiation f...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73405 | biostudies-arrayexpress
TranscriptomicsPI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis
This SuperSeries is composed of the following subset Series: GSE25170: MYC drives resistance to PI3K/mTOR targeted inhibition (Sty SNP array) GSE25172: MYC drives resistance to PI3K/mTOR targeted inhibition (gene expression) Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-25173 | biostudies-arrayexpress
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
TranscriptomicsEIF3B knockdown
Eukaryotic translation initiation factor 3B (EIF3B) knockdown in SMMC-7721 cells EIF3B vs. Scramble siRNA
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67594 | biostudies-arrayexpress
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