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TranscriptomicsTargets of the transcription factor Brachyury in differentiating mouse ES cells
Brachyury (or T) is expressed in the primitive streak, tailbud and notochord of the early mouse embryo (Herrmann et al., 1990; Wilkinson et al., 1990). It plays a key role in early development: mouse embryos lacking functional Brachyury protein fail to gastrulate properly, do not form a differentiat...
ORGANISM(S): Mus musculus 
2012-05-28 | E-GEOD-16646 | biostudies-arrayexpress
TranscriptomicsExpression data from the basolateral amygdala of Long-Evans rats with a history of limited intermittent sucrose snacks
To study the molecular mediators of naturally rewarding effects of palatable food we used a model of palatable “snacking” (Ulrich-Lai et al., 2007) in which rats are given chronic, brief access to a limited amount of sucrose solution (30%). Single housed, male Long-Evans rats (250g) (n=12 per...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20344 | biostudies-arrayexpress
UnknownMercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.
Not available
S-EPMC5455766 | biostudies-literature
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
TranscriptomicsStrategies for in vivo screening and mitigation of hepatotoxicity associated with antisense drugs
In this study we tested and modeled the hepatotoxic potential of locked nucleic acid-containing phosphorothioated antisense oligonucleotide (ASOs) gapmers designed to target human BACH1 and PAR-2 transcripts. Using RNA extracted from mouse livers we compared expression profiles of off-target (i.e. g...
ORGANISM(S): Mus musculus 
2017-08-02 | E-MTAB-5180 | biostudies-arrayexpress
TranscriptomicsCircular RNAs are enriched in anucleate platelets and are a signature of transcriptome degradation
In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified on a transcriptome-wide level. As circular RNAs (circRNAs) are resistant to degradation by exonucleases, their ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-69192 | biostudies-arrayexpress
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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