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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
UnknownCapecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant Breast and Bowel Project trial R-04.
Not available
S-EPMC4050205 | biostudies-literature
UnknownInduction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.
Not available
S-EPMC6014061 | biostudies-literature
ProteomicsProfiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling
Aberrantly high mTORC1 signaling is a known driver of many cancers and human disorders, yet pharmacological inhibition of mTORC1 rarely confers durable clinical responses. To explore alternative therapeutic strategies, herein we conducted a proteomics survey to identify cell surface proteins upregul...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-06-17 | MSV000083988 | MassIVE
ProteomicsBC-APPS1: Anti-progestin therapy targets hallmarks of breast cancer risk through epithelial-stromal remodelling
Breast cancer (BC) is the leading cause of women's cancer death worldwide. Here, in the BC – Anti Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assess whether progesterone receptor antagonism with ulipristal acetate (UA) for 12 weeks reduces surrogate markers of BC risk in 24 premenopausa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD067122 | Pride
Prevention Breast cancer Laser capture proteomics 
UnknownFCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.
Not available
S-EPMC4151214 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
UnknownImmune-correlates analysis of an HIV-1 vaccine efficacy trial.
Not available
S-EPMC3371689 | biostudies-literature
UnknownThe genomic landscape of pediatric acute lymphoblastic leukemia.
Not available
S-EPMC9700506 | biostudies-literature
GenomicsPS
Psoriasis cases as part of WTCCC2 phase 2
EGAD00010000124 | EGA
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