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TranscriptomicsChanges in gene expression in the retina of diabetic Long Evans rats after one, four, and twelve weeks of diabetes
Purpose. Patients with diabetic retinopathy may experience severe vision loss due to macular edema and neovascularization secondary to vascular abnormalities. However, before these abnormalities become apparent, there are functional deficits in contrast sensitivity, color perception, and dark adapta...
ORGANISM(S): Rattus norvegicus 
2011-10-31 | E-GEOD-28831 | biostudies-arrayexpress
TranscriptomicsTargets of the transcription factor Brachyury in differentiating mouse ES cells
Brachyury (or T) is expressed in the primitive streak, tailbud and notochord of the early mouse embryo (Herrmann et al., 1990; Wilkinson et al., 1990). It plays a key role in early development: mouse embryos lacking functional Brachyury protein fail to gastrulate properly, do not form a differentiat...
ORGANISM(S): Mus musculus 
2012-05-28 | E-GEOD-16646 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression after epigentic targeted therapy in T-cell prolymphocytic leukemia (T-PLL)
Epigenetic therapy overcame alemtuzumab resistance in patients with relapsed T-cell prolymphocytic leukemia and induced the expression of treatment related genes. Method: patient PBMCs from Ficoll, normal patient PBMCS enriched for CD3+/CD8+ or CD3+/CD8+/CD45RA+/CCR7- were extracted in Trizol. Con...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-GEOD-67368 | biostudies-arrayexpress
UnknownT-follicular helper cell expansion and chronic T-cell activation are characteristic immune anomalies in Evans syndrome.
Not available
S-EPMC8777200 | biostudies-literature
UnknownNotch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
Not available
S-EPMC4314725 | biostudies-literature
UnknownMetabolic control of regulatory T cell (Treg) survival and function by Lkb1.
Not available
S-EPMC5703326 | biostudies-literature
TranscriptomicsGene expression changes in Itpr triple conditional knockout T cell progenitors
Calicum plays critical roles in developing T cells, promoting survival, proliferation, and differentiation at multiple stages of maturation. Calcium release from intracellular stores due to T cell receptor and pre-T cell receptor signaling is thought to require the inositol triphosphate receptors (I...
ORGANISM(S): Mus musculus 
2014-05-28 | E-GEOD-57997 | biostudies-arrayexpress
TranscriptomicsMicro-RNAs in Adult Long-Evans (Turku/AB) Rat Liver are Refractory to 96 Hours Dioxin Treatment
Dioxin-like chemicals are well-known for their ability to upregulate expression of numerous genes via the AH receptor (AHR). However, recent transcriptomic analyses in several laboratories indicate that dioxin-like chemicals or AHR genotype itself also can downregulate levels of mRNAs encoded by nu...
ORGANISM(S): Rattus norvegicus 
2007-08-14 | E-GEOD-8469 | biostudies-arrayexpress
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