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UnknownOutcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease.
Not available
S-EPMC4162497 | biostudies-literature
UnknownInherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.
Not available
S-EPMC4375304 | biostudies-literature
TranscriptomicsTranscription profiling of human leukemia cells treated with mercaptopurine and/or methotrexate
To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-412 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ALL exhibiting cross-resistance to prednisolone, vincristine, asparaginase and daunorubicinchemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients, and used a genome-wide approac...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human drug sensitive and resistant ALL cells obtained at diagnosis from 174 patients
Cellular drug resistance is associated with an unfavorable prognosis in pediatric acute lymphoblastic leukemia (ALL). To identify genes conferring resistance to antileukemic agents, we analyzed the expression of >12,700 genes in sensitive and resistant ALL cells obtained at diagnosis from 174 patien...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-635 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B- and T-lineage) sensitive to vincristine by the MTT in vitro sensitivity assay
primary ALL cells (B- and T-lineage) sensitive to vincristine by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-648 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary ALL cells (B- and T-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
primary ALL cells (B- and T-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-643 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B- and T-lineage) sensitive to daunorubicinby the MTT in vitro sensitivity assay
primary ALL cells (B- and T-lineage) sensitive to daunorubicinby the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-650 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ALL cells resistant prednisalone
primary ALL cells (B-lineage) resistant to prednisolone by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assayDNR resistant B-ALL
primary ALL cells (B-lineage) resistant to daunorubicin by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-660 | biostudies-arrayexpress
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