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ProteomicsInhibition of the Histone Deacetylase activity impacts on Glioblastoma secretome and disrupts the molecular signature of the Tumor Extracellular Matrix
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor in adults and remains almost invariably lethal due to its aggressive and invasive behavior. Despite many clinical trials have been put forward, the standard treatment that stands for more than a decade consists of surgical resect...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD022982 | Pride
Glioblastoma secretome Histone deacetylase activity Lc-ms/ms 
ProteomicsO-GlcNAcase activity is necessary for the molecular signature of the Glioblastoma secretome
Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use nowadays. Although sugar metabolism through the hexosamine biosynthetic pathway (HBP) plays a key role in tumor aggressiveness and progression in different types of cancer, whether...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019496 | Pride
Glioblastoma secretome Lcms O-glcnacase activity 
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