Sort   by:  
 Page size 
TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-39103 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-09 | E-GEOD-34729 | biostudies-arrayexpress
TranscriptomicsEffects of EVI1 and EVI1?324 mild expression in HeLa cells
We studied the variations of mRNA amounts after Flag-EVI1, Flag-EVI1?324, or Flag expression in HeLa cells. Despites EVI1 discovery in 1988, its recognized role as a dominant oncogene in myeloid leukemia and more recently in epithelial cancers, only a few target genes were known and it was not clea...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-42251 | biostudies-arrayexpress
TranscriptomicsEffects of Evi1 knockdown and overexpression in SKOV-3 ovarian carcinoma cells
We studied the variations of mRNA amounts after Evi1 knockdown or Flag-Evi1 overexpression in SKOV-3 cells. Despites Evi1 discovery in 1988, its recognized role as a dominant oncogene in myeloid leukemia and more recently in epithelial cancers, only a few target genes were known and it was not clear...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-25212 | biostudies-arrayexpress
TranscriptomicsEffects of EVI1 mild expression in HeLa cells
We studied the variations of mRNA amounts after Flag-EVI1 or Flag expression in HeLa cells. Despites EVI1 discovery in 1988, its recognized role as a dominant oncogene in myeloid leukemia and more recently in epithelial cancers, only a few target genes were known and it was not clear why EVI1 was in...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-33724 | biostudies-arrayexpress
TranscriptomicsEVI1 promotes tumor growth via transcriptional repression of MS4A3
Background: The transcription factor EVI1 regulates cellular proliferation, differentiation, and apoptosis, and contributes to an aggressive course of disease in myeloid leukemias and other malignancies. Notwithstanding, knowledge about the target genes mediating its biological and pathological func...
ORGANISM(S): Homo sapiens 
2015-08-30 | E-GEOD-60100 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of binding sites of Evi1 in human myeloid cell lines
The EVI1 gene codes for a transcription factor with important roles in development and leukemogenesis. Overexpression of EVI1 in acute myeloid leukemia (AML) is one of the worst prognostic factors in patients with and without 3q26 rearrangements. Evi1 acts in several pathways through the interaction...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-16238 | biostudies-arrayexpress
GenomicsEVI1 and AP1 Interact to Transcriptionally Regulate a Feed-Forward Loop Important for Cancer Cell Proliferation and Adhesion
This SuperSeries is composed of the following subset Series: GSE25210: Genome-wide mapping of Flag-Evi1 in SKOV-3 ovarian carcinoma cells GSE25212: Effects of Evi1 knockdown and overexpression in SKOV-3 ovarian carcinoma cells GSE33724: Effects of EVI1 mild expression in HeLa cells Refer to individu...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-25213 | biostudies-arrayexpress
TranscriptomicsWhole genome expression profiling of Evi1-GFP positive and negative murine hematopoietic stem cell sub-populations.
Murine hematopoietic stem cells were sorted by FACS from C57BL/6 Evi1+/GFP mice. Gene expression profiles of LSKCD41–CD48–CD150+CD34+ cells, LSKCD41–CD48–CD150+CD34–Evi1-GFP– cells, and LSKCD41–CD48–CD150+CD34–Evi1-GFP+ cells were generated.
ORGANISM(S): Mus musculus 
2020-11-27 | E-MTAB-7321 | biostudies-arrayexpress
Sort   by:  
 Page size