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UnknownPR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function.
Not available
S-EPMC3193263 | biostudies-literature
TranscriptomicsAffymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7
Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress
TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-09 | E-GEOD-34729 | biostudies-arrayexpress
UnknownMDS1 and EVI1 complex locus (MECOM): a novel candidate gene for hereditary hematological malignancies.
Not available
S-EPMC5792286 | biostudies-literature
UnknownDirect interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Not available
S-EPMC6379669 | biostudies-literature
UnknownMecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
Not available
S-EPMC10509669 | biostudies-literature
TranscriptomicsAberrant EVI1 splicing contributes to EVI1-rearranged leukemia [mouse_RNA-seq]
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here...
ORGANISM(S): Mus musculus 
2022-06-21 | GSE190655 | GEO
GenomicsAberrant EVI1 splicing contributes to EVI1-rearranged leukemia (ChIP-Seq)
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here...
ORGANISM(S): Homo sapiens 
2022-06-21 | GSE202207 | GEO
TranscriptomicsAberrant EVI1 splicing contributes to EVI1-rearranged leukemia [K562_RNA-seq]
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 at MECOM drive inv(3)/t(3;3) myeloid leukemias and revealed MECOM germline mutations in patients with MECOM-associated bone marrow failure syndromes. Here...
ORGANISM(S): Homo sapiens 
2022-06-21 | GSE190653 | GEO
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