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MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
TranscriptomicsAttenuation of miR-126 activity expands HSC in vivo without exhaustion
Life-long blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks making them attractive candid...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-40458 | biostudies-arrayexpress
ProteomicsMultiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming
T-cell exhaustion occurs when T cells are chronically activated, usually in the context of cancer or chronic infection. Exhausted T cells lose effector functions, upregulate inhibitory receptors, and lose proliferation ability. Understanding the mechanisms of T-cell exhaustion is important as it has...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD057703 | Pride
Human Phosphoproteomics Metabolomics T-cells Cd4+ Proteomics T-cell exhaustion 
TranscriptomicsMolecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients
In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become M-bM-^@M-^]exhaustedM-bM-^@M-^], characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only li...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-24536 | biostudies-arrayexpress
ProteomicsPD-L1 overexpression, SWI/SNF complex Deregulation and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4+ T Cells
The growing tumor avoids recognition and destruction by immune system. During continuous stimulation of tumor infiltrating lymphocytes (TILs) by tumor, TILs become functionally exhausted. Thus, they become unable to kill tumor cells and to produce some cytokines, and lose their ability to proliferat...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-02-17 | PXD026447 | Pride
Cd4+ effector t cells  t cell exhaustion  swi/snf complex  pd-1  pd-l1  pd-l1/pd-1 axis 
GenomicsMonocyte exhaustion mediated by TRAM
Monocyte exhaustion mediated by TRAM
PRJNA755992 | ENA
GenomicsNLRP3 deficiency reverts intratumoral T cell exhaustion
NLRP3 deficiency reverts intratumoral T cell exhaustion
PRJNA825390 | ENA
GenomicsReversible mitochondrial dysfunction drives terminal T-cell exhaustion
Reversible mitochondrial dysfunction drives terminal T-cell exhaustion
PRJNA575910 | ENA
GenomicsTicam2 ablation facilitates monocyte exhaustion recovery after sepsis
Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis
PRJNA1134159 | ENA
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