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MetabolomicsLC-MS lipidomic characterization of plant-derived exosome-like nanovesicles from ginseng, pueraria lobata, and Chinese yam

This study characterizes the lipid composition of exosome-like nanovesicles isolated from Ginseng, Pueraria lobata, and Chinese yam using LC-MS-based lipidomics. The dataset includes LC-MS raw data and processed lipid annotation and relative quantification tables acquired in both positive and neg...

2026-07-27 | MTBLS14935 | MetaboLights
MetabolomicsUrinary Extracellular Vesicle Metabolomic Profiling Reveals a Distinct Molecular Signature for the Non-Invasive Diagnosis of Lupus Nephritis

Background: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), underscoring an urgent need for non-invasive diagnostic biomarkers. 

Objective: This study aimed to define the metabolomic signature of urinary e...

2026-02-11 | MTBLS13839 | MetaboLights
MetabolomicsCharacterization of small intracellular vesicles uncovers their potential as drug carriers and therapeutic agents

Small extracellular vesicles (sEVs) have been extensively investigated as a source of clinically relevant cargo. Alongside the secretion of EVs, such as exosomes, cells house a multitude of internal vesicles involved in various physiologic processes and metabolic activities. Herein, we developed ...

2025-09-02 | MTBLS12923 | MetaboLights
ProteomicsLFQ of GFP-Trap IP-MS from MEF cells expressing GFP-WIPI2d
Control or GFP-WIPI2d expressing MEFs were treated with or without 0.5uM Apilimod for one hour, and then cross-linked with 0.1% formaldehyde for ten mins at room temperature. After cross-linking was quenched with 100mM glycine for four mins at room temperature, cells were washed with HEPES saline co...
ORGANISM(S): Mus Musculus (mouse) 
2024-06-25 | PXD043701 | JPOST Repository
ProteomicsLFQ of GFP-Trap IP-MS from MEF cells expressing GFP-Rubicon
Control or GFP-Rubicon expressing MEFs were treated with or without 0.5uM Apilimod for one hour, and then cross-linked with 0.1% formaldehyde for ten mins at room temperature. After cross-linking was quenched with 100mM glycine for four mins at room temperature, cells were washed with HEPES saline c...
ORGANISM(S): Mus Musculus (mouse) 
2024-06-25 | PXD043695 | JPOST Repository
ProteomicsHuh-7 exosomes and HBV
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080794 | MassIVE
TranscriptomicsExosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)
Background: Docosahexaenoic acid (DHA) is a natural compound with anticancer and anti-angiogenesis activity that is currently under investigation as both a preventative agent and an adjuvant to breast cancer therapy. However, the precise mechanisms of DHA’s anticancer activities are unclear. It is u...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-70432 | biostudies-arrayexpress
TranscriptomicsMelanoma-derived exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through upregulation of the MET oncoprotein.
Tumor-derived exosomes are emerging as mediators of tumorigenesis with a tissue-specific address and message. We explored the function of melanoma-derived exosomes in formation of primary tumors and metastatic progression in both murine models and patients. Whereas exosomes from highly metastatic me...
ORGANISM(S): Mus musculus 
2012-05-26 | E-GEOD-36584 | biostudies-arrayexpress
ProteomicsConnecting extracellular vesicle uptake and exosome biogenesis: intercellular communication in breast cancer cells is ITGB3-dependent
Metastasis, the spread of malignant cells from the primary tumour to distant sites is in 90% of the cases, the ultimate cause cancer related death. The integrin ITGB3 has been previously described to play an essential role in breast cancer metastasis, but the precise mechanisms remain undefined. We ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD013489 | Pride
Breast cancer Itgb3 Extracellular vesicle 
ProteomicsAccessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation
Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7-positive multivesicular endosomes, and also in recycling Rab11a-positive endosomes, particularly under some forms of nutrient stress. The core proteins of the En...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD040361 | Pride
Escrt/ chmp5/ extracellular vesicle/ rab11a-exosome/ recycling endosome 
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