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TranscriptomicsTranscriptome profiling of a backcross between experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains to identify expression quantitative trait loci.
The aim of the experiment is to characterize the genetics and mechanisms of the inflammatory response after induction of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by studying the genome wide expression in the spleen in late disease. A backcross was created betwe...
ORGANISM(S): Rattus norvegicus 
2013-08-10 | E-MTAB-784 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rat strains stimulated with myelin oligodendrocyte glycoprotein (MOG) to identify the alternative splicing.
Experimental autoimmune encephalomyelitis (EAE)-susceptible DA and EAE-resistant PVG rats were immunized with myelin oligodendrocyte glycoprotein (MOG) to induce an autoimmune response.
Seven days later draining inguinal lymph nodes were removed. 2 conditions were examined: 'ex vivo' and 'MOG res...
ORGANISM(S): Rattus norvegicus 
2009-11-01 | E-MEXP-2237 | biostudies-arrayexpress
TranscriptomicsGene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
Myelin Basic Protein (MBP) induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat, produces an an acute weakness, or paralysis of the tail and hind limb ataxia ,weakness or paralysis associated with increased permiability of the blood brain barrier, inflammation and demyelination i...
ORGANISM(S): Rattus norvegicus 
2013-04-03 | E-GEOD-39119 | biostudies-arrayexpress
TranscriptomicsGene expression data from polarized T helper cells isolated from mice with opticospinal (OSE) experimental autoimmune encephalomyelitis (EAE)
T cells from the spleen of a mixed-gender pool of four double-transgenic 2D2 (TCRMOG) x IgHMOG mice (OSE) mice, which spontaneously develop experimental autoimmune encephalomyelitis (EAE), were used to derive TH1- and TH17-polarized cells, as described in https://doi.org/10.1371/journal.pone.0015531...
ORGANISM(S): Mus musculus 
2020-08-21 | E-MTAB-9133 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse experimental autoimmune encephalomyelitis (EAE) from spinal cord preparations of opticospinal EAE (OSE) and MOG-induced EAE
Genetic opticospinal EAE (OSE) and MOG-induced EAE (MOG-EAE) are two experimental autoimmune encephalomyelitis (EAE) mouse models of human multiple sclerosis. For the OSE model, double-transgenic 2D2 (TCRMOG) x IgHMOG mice were used. For MOG-EAE, wildtype C57BL/6 mice were immunized with a MOG pept...
ORGANISM(S): Mus musculus 
2020-08-21 | E-MTAB-9132 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of monocytes and microglia from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
The role of microglia and infiltrating monocytes in experimental autoimmune encephalomyelitis (EAE) pathogenesis has been controversial. To gain insight into their respective roles, we developed a method for differentiating between microglia and infiltrating monocytes in the CNS using CD44. We used ...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-59725 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations induced by AT-EAE in mouse spinal cord
We compared RNA samples extracted from spinal cords of control (C) and AT-EAE (E) mice using the "Multiple Yellow" strategy. 4 distinct C-extracts were hybridized with two slides and 4 distinct E-extracts with other two slides, and the green/red normalized signals were compared separately and the E/...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2446 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spinal cords from B10.PL mice with severe (stage 2.5-3) experimental autoimmune encephalomyelitis treated with placebo or 1,25-dihydroxyvitamin D3 to study the molecular mechanism of the compound.
B10.PL mice with severe (stage 2.5-3) experimental autoimmune encephalomyelitis were treated with placebo or 200 ng 1,25(OH)2D3. Six hours later, the spinal cords were harvested and mRNA was extracted for microarray analysis. Naive mice serve as controls. Individual samples were hybridized to ind...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-842 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat spinal cord with experimental autoimmune encephalomyelitis at 3 disease points, acute, relapsing and recovering vs. controls
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first E...
ORGANISM(S): Rattus norvegicus 
2007-05-15 | E-MEXP-1025 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of rat SJL sub-strains of an experimental autoimmune encephalomyelitis (EAE) rodent model of Multiple Sclerosis (MS)
Copy number variation in two SJL sub-strains of an experimental autoimmune encephalomyelitis (EAE) rodent model of Multiple Sclerosis (MS)
ORGANISM(S): Mus musculus 
2010-02-26 | E-MEXP-2534 | biostudies-arrayexpress
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