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MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
ProteomicsProteomic Profiling of Kidney Organoids in Extended Culture Conditions
We conducted a global proteomics analysis on kidney organoids at three distinct culture time points: day 22, day 33, and day 38. Our objective wasto investigate the impact of extended culture, beyond the standard differentiation endpoint of day 21, on the organoid protein expression profile.
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD057360 | Pride
Proteomics Kidney organoids Extended culture Renal disease modeling 
GenomicsGeneration of an EHE Extended Primary Cell Culture
Generation of an EHE Extended Primary Cell Culture
PRJNA1162515 | ENA
GenomicsSpontaneous Immortalization of Bovine Fibroblasts through Extended In Vitro Culture
Spontaneous Immortalization of Bovine Fibroblasts through Extended In Vitro Culture
PRJNA1187454 | ENA
GenomicsExtended culture of 2D gastruloids to model human mesoderm development
Extended culture of 2D gastruloids to model human mesoderm development
PRJNA1090137 | ENA
GenomicsExtended-culture and culture-independent molecular analysis of the airway microbiota in cystic fibrosis following CFTR modulation with ivacaftor.
Extended-culture and culture-independent molecular analysis of the airway microbiota in cystic fibrosis following CFTR modulation with ivacaftor.
PRJEB37510 | ENA
TranscriptomicsMicroarray analysis of HCT‑116 cells during in vitro culture over time
Human cancer cell lines are frequently used in controlled culture systems to investigate cancer biology. However, extended cultivation can introduce genomic and transcriptional instability. The cell line HCT-116 is a well characterized and widely used model for colorectal cancer. To assess transcrip...
ORGANISM(S): Homo sapiens 
2026-04-07 | E-MTAB-16637 | biostudies-arrayexpress
GenomicsEpigenetic and metabolic remodeling during the acquisition of extended pluripotency
Epigenetic and metabolic remodeling during the acquisition of extended pluripotency
PRJNA564808 | ENA
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