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TranscriptomicsA combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis
Extracellular matrix interactions play essential roles in normal physiology and many pathological processes. Here, we report a novel screening platform capable of measuring phenotypic responses to combinations of ECM molecules. While the importance of ECM interactions in metastasis is well documente...
ORGANISM(S): Mus musculus 
2012-10-11 | E-GEOD-40222 | biostudies-arrayexpress
TranscriptomicsAnalysis of extracellular matrix and adhesion molecules expression in ALL cell line
The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-18516 | biostudies-arrayexpress
MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
TranscriptomicsThe expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
We examined the effect of IL-17 signaling pathway on extracellular matrix (ECM) expression and the involvement of IL-17 signaling pathway in pathogenesis of SSc. To identify differences in the expression pattern of ECM genes in IL-17A- or IL-17F-treated cells, we performed PCR array analysis, consis...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33581 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of extracellular matrix-related genes in the presence or absence of EBI3 in the PCR array
We performed a PCR array of 84 ECM-related genes using RNA obtained from dermal fibroblasts stimulated with or without EBI3. 18 of the 84 genes were upregulated and 22 genes were downregulated in EBI3-treated fibroblasts in comparison with untreated cells. In the present study, we examined the invol...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-68649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ hematopoietic cells grown in suspension culture or in a collegen I matrix
CD34+ hematopoietic stem/progenitor cells (HSC) reside in the bone marrow in close vicinity to the endosteal bone surface, surrounded by osteoblasts, stromal cells and various extracellular matrix molecules. We utilized a bioartificial matrix containing fibrillar collagen I, the major matrix compone...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-3003 | biostudies-arrayexpress
GenomicsElimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan modifies the expression of key molecules of synapse formation and transmission
Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan modifies the expression of key molecules of synapse formation and transmission
PRJNA524355 | ENA
ProteomicsSelection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules
Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), there is a relative paucity of studies at the protein level. Here, we perform a deep, multi-omic characterization (epigenome, transcriptome and proteome) of HSCs carrying a loss-of-funct...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-13 | PXD059814 | Pride
Hematopoietic stem cell Extracellular matrix molecules 
TranscriptomicsRole of miRNAs in acute kidney injury recovery induced by mesenchymal stromal cells and derived extracellular vesicles.
Phenotypic changes induced by extracellular vesicles (EVs) have been implicated in the recovery of acute kidney injury (AKI) induced by mesenchymal stromal cells (MSCs). miRNAs are potential candidates for cell reprogramming towards a pro-regenerative phenotype. The aim of the present study was to e...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-59958 | biostudies-arrayexpress
TranscriptomicsTenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]
We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gl...
ORGANISM(S): Mus musculus 
2011-10-19 | E-GEOD-33091 | biostudies-arrayexpress
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