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MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
MetabolomicsLipidomic analysis of Toxoplasma gondii extracellular vesicles across host cell types

Introduction. Toxoplasma gondii is an obligate intracellular parasite with an exceptional capacity to colonize a broad range of host species and cell types. Successful infection depends on its ability to manipulate host metabolism, including lipid pathways that are essential for membrane biogenes...

2026-02-11 | MTBLS13253 | MetaboLights
TranscriptomicsmiRNA expression of extracellular vesicles
To further investigate the molecular mechanisms by which EVs mediated the abnormal localization of tight junction proteins and adherence junction protein, we performed miRNA microarray analysis of extracellular vesicles isolated from breast cancer cells. miRNA expression in extracellular vesicles wa...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-63445 | biostudies-arrayexpress
TranscriptomicsExtracellular Vesicles in Luminal Fluid of the Ovine Uterus
Exosomes/microvesicles (hereafter referred to as extracellular vesicles) were isolated from the ULF of day 14 cyclic and pregnant ewes using ExoQuick-TC. Extracellular vesicle RNA was pooled (n=4 per status) and analyzed for small RNAs by sequencing on the Ion Torrent PGM platform and analysis with ...
ORGANISM(S): Ovis aries 
2014-01-11 | E-GEOD-53974 | biostudies-arrayexpress
GenomicsDirectional endothelial communication by polarized extracellular vesicle release
Directional endothelial communication by polarized extracellular vesicle release
PRJNA967339 | ENA
TranscriptomicsComparative transcriptomic analysis of human and Drosophila extracellular vesicles reveals extensive conservation
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevai...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-76173 | biostudies-arrayexpress
TranscriptomicsCELL-EXO_01
In this study, we address mRNA composition of hepatocyte-like derived extracellular vesicles (EVs), using as cellular model the mouse liver derived cell line MLP29, and primary cell culture of rat hepatocyte (RH) obtained by in vivo liver perfusion. The study shows qualitative characterization of ...
ORGANISM(S): Rattus norvegicus 
2013-07-23 | E-MEXP-3740 | biostudies-arrayexpress
TranscriptomicsmRNA expression of brain endothelial cells
To investigate the mRNA expression after extracellular vesicles or miRNA treatement, global gene expression analysis was performed in endothelial cells after the transfection of N.C. or miR-181c and or after the addition of extracellular vesicles from cancer cells. mRNA expression in brain endotheli...
ORGANISM(S): Macaca fascicularis 
2015-04-02 | E-GEOD-63447 | biostudies-arrayexpress
GenomicsDirectional endothelial communication by polarized extracellular vesicle release
Directional endothelial communication by polarized extracellular vesicle release
PRJNA958118 | ENA
GenomicsDirectional endothelial communication by polarized extracellular vesicle release
Directional endothelial communication by polarized extracellular vesicle release
PRJNA958200 | ENA
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