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MetabolomicsQuantitative Metabolomic Dataset of Avian Eye Lenses

Metabolomics is a powerful set of methods that uses analytical techniques to identify and quantify metabolites in biological samples, providing a snapshot of the metabolic state of a biological system. In medicine, metabolomics can help diagnose diseases, reveal molecular basis of a disease, and ...

2023-06-30 | MTBLS7739 | MetaboLights
MetabolomicsOvothiol A is the Main Antioxidant in Fish Lens
Tissue protection from oxidative stress by antioxidants is of vital importance for cellular metabolism. The lens mostly consists of fiber cells lacking nuclei and organelles, having minimal metabolic activity; therefore, the defense of the lens tissue from the oxidative stress strongly relies on met...
2019-07-30 | MTBLS806 | MetaboLights
MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
MetabolomicsThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights
TranscriptomicsRegulation of Mouse Lens Development and Gene Expression by Krüppel-Like Factor 4
Conditional disruption of Klf4 in the ectoderm-derived tissues of the eye results in defective cornea, conjunctiva and the lens. Expression of Klf4 is first detected in the embryonic day-12 (E12) mouse lens, peaks at E16, and declines thereafter. Lenses from Mice which were conditional null for Klf4...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47694 | biostudies-arrayexpress
TranscriptomicsDifferentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens.
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that require a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens. The lens epithelium overlies a core of terminally differentiated fiber cells that must degr...
ORGANISM(S): Gallus gallus 
2014-07-02 | E-GEOD-53976 | biostudies-arrayexpress
TranscriptomicsDevelopmental timecourse of mouse ocular lens and whole embryo control
Identification of genes involved in ocular birth defects remains a challenge. To facilitate the identification of genes associated with cataract, we developed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE contains microarray gene express...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32334 | biostudies-arrayexpress
TranscriptomicsComparison of lens gene expression between the control and DicerCN mouse embryos at E13.5
In order to investigate the mechanism for the progressive lens degeneration caused by targeted deletion of Dicer, we compared expression profiles of protein-coding genes in wild type and DicerCN lenses at E13.5, at a time before gross morphological changes had occurred. We identified distinct class...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lens epithelial cells to examine glucocorticoid induced changes
Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3040 | biostudies-arrayexpress
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