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ProteomicsTear proteins altered in patients with persistent eye pain after refractive surgery: biomarker candidate discovery
Some patients develop persistent eye pain after refractive surgery, but the factors that cause or sustain pain are unknown. We tested whether tear proteins of patients with pain 3 months after surgery differ from patients without pain. Patients undergoing refractive surgery (LASIK or PRK) were recru...
ORGANISM(S): Homo sapiens (Human) 
2025-05-25 | PXD051071 | Pride
Corneal pain Eye pain Mass spectrometry Prk Human tears Lasik Quantitative proteomics Biomarker Tandem mass tags 
TranscriptomicsTranscription profiling of Drosophila eye antennal imaginal disc expressing either activated Ras or secreted Spitz
We have used microarrays to identify genes expressed and required for the second mitotic wave (SMW) during eye development. Eye discs expressing Spitz under the control of GMR Gal4 have no SMW as Spitz promotes G1 arrest, ectopic differentiation also occures. To control for the ectopic differentiati...
ORGANISM(S): Drosophila melanogaster 
2008-06-14 | E-GEOD-6300 | biostudies-arrayexpress
GenomicsDifferential Methylation Of The TRPA1 Promoter In Pain Sensitivity: MeDIP-sequencing
Chronic pain is a global public health problem, but the underlying molecular mechanisms are not fully understood. Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. Whole blood DNA methylation wa...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-52965 | biostudies-arrayexpress
UnknownModification of the Neuropathic Pain Symptom Inventory for use in eye pain (NPSI-Eye).
Not available
S-EPMC6586475 | biostudies-literature
UnknownNeuropathic ocular pain: an important yet underevaluated feature of dry eye.
Not available
S-EPMC4366454 | biostudies-literature
UnknownChronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders.
Not available
S-EPMC4411662 | biostudies-literature
TranscriptomicsComparison of wild-type and Mfsd2a KO eye cups
Eye photoreceptor membrane discs in outer rod segments are highly enriched in the visual pigment rhodopsin and the omega-3 fatty acid docosahexaenote (DHA). The eye acquires DHA from blood, but transporters for DHA uptake across the blood-retinal barrier (BRB) or retinal pigment epithelium have not ...
ORGANISM(S): Mus musculus 
2016-03-23 | E-GEOD-77403 | biostudies-arrayexpress
UnknownRelationship between ocular surface pain and corneal nerve loss in dry eye diabetics: a cross-sectional study in Shenyang, China.
Not available
S-EPMC10533686 | biostudies-literature
TranscriptomicsWnt ligands from the embryonic surface ectoderm regulate bimetallic strip optic cup morphogenesis in the mouse
Wnt signaling in early eye development, specifically the lens placode shows expression of 12 out of 19 Wnt ligands. We these Wnt activities were suppressed using conditional deletion of Wntless, dramatic phenotypic changes in morphogensis occurred. Microarray analysis of the genes that were changed...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65154 | biostudies-arrayexpress
UnknownPain sensitivity and autonomic nervous system parameters as predictors of dry eye symptoms after LASIK.
Not available
S-EPMC7867610 | biostudies-literature
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