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UnknownOrganizational factors associated with adherence to low tidal volume ventilation: a secondary analysis of the CHECKLIST-ICU database.

Background

Survival benefit from low tidal volume (VT) ventilation (LTVV) has been demonstrated for patients with acute respiratory distress syndrome (ARDS), and patients not having ARDS could also benefit from this strategy. Organizational factors may play a role on adherence to ...
S-EPMC7266115 | biostudies-literature
UnknownHydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.

Background

Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

Methods

We conducted a multicenter, randomized, open-label, three-group, controlled tri...
S-EPMC7397242 | biostudies-literature
UnknownMultifaceted Strategy Based on Automated Text Messaging After a Recent Heart Failure Admission: The MESSAGE-HF Randomized Clinical Trial.

Importance

Readmissions after an index heart failure (HF) hospitalization are a major contemporary health care problem.

Objective

To evaluate the feasibility and efficacy of an intensive telemonitoring strategy in the vulnerable period after an HF hospitalization.

Design, setting, ...

S-EPMC10701668 | biostudies-literature
UnknownZika Virus Surveillance at the Human-Animal Interface in West-Central Brazil, 2017-2018.
Zika virus (ZIKV) was first discovered in 1947 in Uganda but was not considered a public health threat until 2007 when it found to be the source of epidemic activity in Asia. Epidemic activity spread to Brazil in 2014 and continued to spread throughout the tropical and subtropical regions of the Ame...
S-EPMC6950091 | biostudies-literature
UnknownDONORS (Donation Network to Optimise Organ Recovery Study): Study protocol to evaluate the implementation of an evidence-based checklist for brain-dead potential organ donor management in intensive care units, a cluster randomised trial.

Introduction

There is an increasing demand for multi-organ donors for organ transplantation programmes. This study protocol describes the Donation Network to Optimise Organ Recovery Study, a planned cluster randomised controlled trial that aims to evaluate the effectiveness of the implementa...
S-EPMC6597655 | biostudies-literature
UnknownKetamine, Etomidate, and Mortality in Emergency Department Intubations.

Importance

The choice of induction agent during rapid sequence intubation (RSI) of critically ill adults may affect clinical outcomes. Although ketamine and etomidate are frequently used for RSI, their comparative effectiveness remains controversial.

Objective

To compare the safety of...
S-EPMC12706683 | biostudies-literature
UnknownEarly Treatment with Pegylated Interferon Lambda for Covid-19.

Background

The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.

Methods

We conducted a randomized, controlled, adaptive platform trial involving predominantly...
S-EPMC9933926 | biostudies-literature
UnknownEffect of Early Treatment with Ivermectin among Patients with Covid-19.

Background

The efficacy of ivermectin in preventing hospitalization or extended observation in an emergency setting among outpatients with acutely symptomatic coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unclear.<...
S-EPMC9006771 | biostudies-literature
UnknownRationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.

Background

Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and...
S-EPMC3543273 | biostudies-literature
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